A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel.
Introduction: Antithrombotic drugs, such as low-dose aspirin (LDA) and clopidogrel, can cause upper gastrointestinal complications.Aim: The goal of the present study was to investigate whether a mucosal-protective agent, rebamipide, could prevent gastric mucosal injuries induced by LDA with or witho...
| Publicado en: | Digestive Diseases & Sciences Vol. 59; no. 8; pp. 1885 - 1891 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Aug2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103890913&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103890913 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01632116 1VP jtl: Digestive Diseases & Sciences issn: 01632116 maglogo: N pubinfo: dt: Aug2014 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103890913 103890913 NLM24659236 2012731316 NLM24659236 103890913 ppf: 1885 ppct: 6 formats: tig: atl: A randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel. aug: au: Tozawa, Katsuyuki Oshima, Tadayuki Okugawa, Takuya Ogawa, Tomohiro Ohda, Yoshio Tomita, Toshihiko Hida, Nobuyuki Fukui, Hirokazu Hori, Kazutoshi Watari, Jiro Nakamura, Shiro Miwa, Hiroto sug: subj: Alanine Gastrointestinal Agents Therapeutic Use Aspirin Adverse Effects Gastrointestinal Hemorrhage Prevention and Control Platelet Aggregation Inhibitors Adverse Effects Antiinfective Agents, Quinolone Therapeutic Use Ticlopidine Adult Alanine Therapeutic Use Double-Blind Studies Gastric Mucosa Injuries Gastrointestinal Hemorrhage Chemically Induced Research Subjects Human Male Peptic Ulcer Chemically Induced Peptic Ulcer Prevention and Control Ticlopidine Adverse Effects Young Adult Adult: 19-44 years Male ab: Introduction: Antithrombotic drugs, such as low-dose aspirin (LDA) and clopidogrel, can cause upper gastrointestinal complications.Aim: The goal of the present study was to investigate whether a mucosal-protective agent, rebamipide, could prevent gastric mucosal injuries induced by LDA with or without clopidogrel in healthy subjects.Materials and Methods: A randomized, double-blind, placebo-controlled trial was performed with 32 healthy male volunteers. Subjects were randomly assigned to a 14-day course of one of the following regimens: group A, placebo (tid) + LDA; group B, rebamipide (100 mg tid) + LDA (100 mg once-daily); group C, placebo + LDA + clopidogrel (75 mg once-daily); or group D, rebamipide + LDA + clopidogrel. The grade of gastric mucosal injuries was evaluated by esophagogastroduodenoscopy before and after dosing (on day 0 and day 14), and the grade of gastric mucosal injury was assessed according to the modified Lanza score. Subjective symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS). A rapid urease test was performed on day 0, and blood tests were performed on day 0 and day 14.Results: Rebamipide significantly inhibited gastric mucosal injury induced by LDA alone or by LDA plus clopidogrel when compared with placebo in healthy subjects. GSRS score and hemoglobin level were not significantly different among the four groups.Conclusions: Rebamipide is useful for the primary prevention of gastric mucosal injury induced by LDA alone or by LDA plus clopidogrel in healthy subjects. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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