Estimation of the Probability of Exposure to Machining Fluids in a Population-Based Case-Control Study.
We describe an approach for estimating the probability that study subjects were exposed to metalworking fluids (MWFs) in a population-based case-control study of bladder cancer. Study subject reports on the frequency of machining and use of specific MWFs (straight, soluble, and synthetic/semi-synthe...
| Publicado en: | Journal of Occupational & Environmental Hygiene Vol. 11; no. 11; pp. 757 - 771 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2014
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103899033&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103899033 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459624 V1L jtl: Journal of Occupational & Environmental Hygiene issn: 15459624 maglogo: Y pubinfo: dt: Nov2014 vid: 11 iid: 11 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 103899033 98563305 10.1080/15459624.2014.918984 NLM25256317 103899033 ppf: 757 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Estimation of the Probability of Exposure to Machining Fluids in a Population-Based Case-Control Study. aug: au: Park, Dong-Uk Colt, Joanne S. Baris, Dalsu Schwenn, Molly Karagas, Margaret R. Armenti, Karla R. Johnson, Alison Silverman, Debra T. Stewart, Patricia A. affil: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Environmental Health, Korea National Open University, Seoul, Korea sug: subj: Occupational Exposure Risk Factors Probability Machinery Utilization Metallurgy Human Maryland Case Control Studies Funding Source Bladder Neoplasms Risk Factors Male Young Adult Adult Middle Age Questionnaires Confidence Intervals Odds Ratio Data Analysis Software Correlation Coefficient Adult: 19-44 years Middle Aged: 45-64 years Male ab: We describe an approach for estimating the probability that study subjects were exposed to metalworking fluids (MWFs) in a population-based case-control study of bladder cancer. Study subject reports on the frequency of machining and use of specific MWFs (straight, soluble, and synthetic/semi-synthetic) were used to estimate exposure probability when available. Those reports also were used to develop estimates for job groups, which were then applied to jobs without MWF reports. Estimates using both cases and controls and controls only were developed. The prevalence of machining varied substantially across job groups (0.1–>0.9%), with the greatest percentage of jobs that machined being reported by machinists and tool and die workers. Reports of straight and soluble MWF use were fairly consistent across job groups (generally 50–70%). Synthetic MWF use was lower (13–45%). There was little difference in reports by cases and controls vs. controls only. Approximately, 1% of the entire study population was assessed as definitely exposed to straight or soluble fluids in contrast to 0.2% definitely exposed to synthetic/semi-synthetics. A comparison between the reported use of the MWFs and U.S. production levels found high correlations (r generally >0.7). Overall, the method described here is likely to have provided a systematic and reliable ranking that better reflects the variability of exposure to three types of MWFs than approaches applied in the past. [Supplementary materials are available for this article. Go to the publisher's online edition ofJournal of Occupational and Environmental Hygienefor the following free supplemental resources: a list of keywords in the occupational histories that were used to link study subjects to the metalworking fluids (MWFs) modules; recommendations from the literature on selection of MWFs based on type of machining operation, the metal being machined and decade; popular additives to MWFs; the number and proportion of controls who reported various MWF responses by job group; the number and proportion of controls assigned to the MWF types by job group and exposure category; and the distribution of cases and controls assigned various levels of probability by MWF type.] pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|