White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder.
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM mi...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 44; no. 11; pp. 2742 - 2755 |
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| Autores principales: | , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103904653&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103904653 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Nov2014 vid: 44 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103904653 98836501 10.1007/s10803-014-2131-9 NLM25074758 103904653 ppf: 2742 ppct: 13 formats: fmt: @attributes: type: P tig: atl: White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder. aug: au: Cooper, Miriam Thapar, Anita Jones, Derek sug: subj: Autism Spectrum Disorder Etiology Brain Physiopathology Attention Deficit Hyperactivity Disorder Etiology Comorbidity In Adolescence Human Funding Source Adolescence Male Right-Handedness Scales Questionnaires Interview Guides Interviews Diagnostic Imaging Equipment and Supplies Data Analysis Software Algorithms Mann-Whitney U Test Case Control Studies Descriptive Statistics Predictive Research Adolescent: 13-18 years Male ab: Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations ( p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case-control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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