Regional disturbances in blood flow and metabolism in equine limb wound healing with formation of exuberant granulation tissue.
As in other fibroproliferative disorders, hypoxia has been suggested to play a key role in the pathogenesis of exuberant granulation tissue ( EGT). The purpose of this study was to investigate metabolism and blood flow locally in full-thickness wounds healing with (limb wounds) and without (body wou...
| Publicado en: | Wound Repair & Regeneration Vol. 22; no. 5; pp. 647 - 654 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep/Oct2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103907574&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103907574 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Sep/Oct2014 vid: 22 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103907574 98980680 10.1111/wrr.12207 NLM24935817 103907574 ppf: 647 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Regional disturbances in blood flow and metabolism in equine limb wound healing with formation of exuberant granulation tissue. aug: au: Sørensen, Mette A. Petersen, Lars J. Bundgaard, Louise Toft, Nils Jacobsen, Stine affil: Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen sug: subj: Wound Healing Physiology Blood Circulation Metabolism Granulation Tissue Animal Studies Horses Models, Biological Anoxia Linear Regression Repeated Measures Data Analysis Software Post Hoc Analysis Funding Source ab: As in other fibroproliferative disorders, hypoxia has been suggested to play a key role in the pathogenesis of exuberant granulation tissue ( EGT). The purpose of this study was to investigate metabolism and blood flow locally in full-thickness wounds healing with (limb wounds) and without (body wounds) formation of EGT. Microdialysis was used to recover endogenous metabolites from the wounds, and laser Doppler flowmetry was used to measure blood flow. Measurements were performed before wounding and 1-28 days after wounding. Blood flow was consistently lower in limb wounds than in body wounds throughout the study period with no change over time. After wounding and throughout the study period, the glucose concentration was significantly lower in limb wounds than in body wounds, whereas the lactate level showed a significantly higher concentration in limb wounds. The lactate/glucose ratio displayed a significant difference between body and limb wounds. In conclusion, the metabolic disturbances may suggest an inadequate oxygen supply during the wound healing process in equine limb wounds healing with EGT. This may be related to the inherently decreased perfusion in the wound bed of limb wounds. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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