Heart rate variability in encephalopathic newborns during and after therapeutic hypothermia.
Objective:To evaluate whether heart rate variability (HRV) measures are predictive of neurological outcome in babies with hypoxic ischemic encephalopathy (HIE).Study Design:This case-control investigation included 20 term encephalopathic newborns treated with systemic hypothermia in a regional neona...
| Publicado en: | Journal of Perinatology Vol. 34; no. 11; pp. 836 - 842 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2014
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103919953&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103919953 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: Nov2014 vid: 34 iid: 11 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 103919953 99626907 10.1038/jp.2014.108 NLM24921413 103919953 ppf: 836 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Heart rate variability in encephalopathic newborns during and after therapeutic hypothermia. aug: au: Massaro, A N Govindan, R B Al-Shargabi, T Andescavage, N N Metzler, M Chang, T Glass, P du Plessis, A J affil: 1] Department of Neonatology, Children's National Medical Center, Washington, DC, USA [2] Department of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA [3] Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA sug: subj: Heart Rate Variability Hypoxia-Ischemia, Brain, Neonatal Therapy Hypothermia Human Infant, Newborn Funding Source Case Control Studies Intensive Care Units, Neonatal Descriptive Statistics Wilcoxon Rank Sum Test Post Hoc Analysis Predictive Value of Tests ROC Curve Infant, Newborn: birth-1 month ab: Objective:To evaluate whether heart rate variability (HRV) measures are predictive of neurological outcome in babies with hypoxic ischemic encephalopathy (HIE).Study Design:This case-control investigation included 20 term encephalopathic newborns treated with systemic hypothermia in a regional neonatal intensive care unit. Electrocardiographic data were collected continuously during hypothermia. Spectral analysis of beat-to-beat heart rate interval was used to quantify HRV. HRV measures were compared between infants with adverse outcome (death or neurodevelopmental impairment at 15 months, n=10) and those with favorable outcome (survivors without impairment, n=10).Result:HRV differentiated infants by outcome during hypothermia through post-rewarming, with the best distinction between groups at 24 h and after 80 h of life.Conclusion:HRV during hypothermia treatment distinguished HIE babies who subsequently died or had neurodevelopmental impairment from intact survivors. This physiological biomarker may identify infants in need of adjuvant neuroprotective interventions. These findings warrant further investigation in a larger population of infants with HIE. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|