Comparative Efficacy of Alcohol-Based Surgical Scrubs: The Importance of Formulation.
Alcohol-based surgical scrubs (ABSSs) are used to prevent surgical site infections. Chlorhexidine gluconate (CHG) often is added to enhance persistent germicidal activity. The aim of this study was to determine the influence of ABSS product formulation on efficacy. We evaluated three commercially av...
| Publicado en: | AORN Journal Vol. 100; no. 6; pp. 641 - 651 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103923063&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103923063 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00012092 1FR jtl: AORN Journal issn: 00012092 maglogo: N pubinfo: dt: 2014 vid: 100 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103923063 99771073 10.1016/j.aorn.2014.03.013 NLM25453683 103923063 ppf: 641 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Comparative Efficacy of Alcohol-Based Surgical Scrubs: The Importance of Formulation. aug: au: Macinga, David R. Edmonds, Sarah L. Campbell, Esther McCORMACK, Robert R. affil: Microbiology and clinical science research fellow for GOJO Industries, Inc, Akron, OH sug: subj: Surgical Wound Infection Prevention and Control Surgical Scrubbing Ethanol Therapeutic Use Chlorhexidine Therapeutic Use Human United States Food and Drug Administration Drug Evaluation Perioperative Nursing Experimental Studies Random Assignment Comparative Studies Data Analysis Software Descriptive Statistics One-Way Analysis of Variance Post Hoc Analysis Confidence Intervals ab: Alcohol-based surgical scrubs (ABSSs) are used to prevent surgical site infections. Chlorhexidine gluconate (CHG) often is added to enhance persistent germicidal activity. The aim of this study was to determine the influence of ABSS product formulation on efficacy. We evaluated three commercially available ABSS formulations and one control alcohol formulation according to the surgical scrub methodology specified by the US Food and Drug Administration (FDA). Only one ABSS formulation met FDA efficacy requirements when tested at the manufacturer's recommended dosage. In contrast, two ABSS formulations, one of which contained CHG, failed to meet the FDA acceptance criteria for a 3-log10 reduction on day 5, meaning the formulations did not sufficiently reduce bacteria levels on hands on the fifth day of product application. The data suggest that recommendations to include CHG in ABSS formulations should be reconsidered, and product efficacy, skin tolerability, and user acceptability should be evaluated on a case-by-case basis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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