Whole-body cooling does not compromise muscle oxidative capacity in subjects with multiple sclerosis.
BACKGROUND: Whole-body cooling improves exercise tolerance in patients with multiple sclerosis (pwMS). To be able to exercise at greater intensities and/or for longer durations with whole-body cooling, it should be examined whether this compromises skeletal muscle oxidative capacity (assessed by exe...
| Published in: | NeuroRehabilitation Vol. 35; no. 4; pp. 805 - 812 |
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| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Sage Publications Inc.
2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103925689&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103925689 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: 2014 vid: 35 iid: 4 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 103925689 99954684 10.3233/NRE-141159 NLM25318769 103925689 ppf: 805 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Whole-body cooling does not compromise muscle oxidative capacity in subjects with multiple sclerosis. aug: au: Op 't Eijnde, Bert Keytsman, Charly Wens, Inez Hansen, Dominique affil: Rehabilitation Research Center (REVAL), Biomed, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium sug: subj: Multiple Sclerosis Muscles Physiology Oxidation-Reduction Cryotherapy Human Case Control Studies Oxygen Metabolism Kinetics Body Temperature Reaction Time Lactates Blood Heart Rate Scales Exercise Test Pearson's Correlation Coefficient Univariate Statistics Paired T-Tests Adult Middle Age Descriptive Statistics Male Female Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: BACKGROUND: Whole-body cooling improves exercise tolerance in patients with multiple sclerosis (pwMS). To be able to exercise at greater intensities and/or for longer durations with whole-body cooling, it should be examined whether this compromises skeletal muscle oxidative capacity (assessed by exercise-onset VO2 kinetics). OBJECTIVE: To study the impact of whole-body cooling on exercise-onset VO2 kinetics in pwMS. METHODS: From 12 pwMS (EDSS 3.5 ± 1.5) and 12 healthy age, BMI, and gender-matched subjects exercise-onset VO2 kinetics (mean response time [MRT]) and body temperature were determined under normothermic and hypothermic (pre-exercise 60-min whole-body cooling) conditions during submaximal exercise testing (two 6-min constant-load exercise bouts). Moreover, heart rate, blood lactate content, expiratory volume and ratings of perceived exertion (RPE) were assessed during exercise. RESULTS: Exercise heart rate (-7 ± 6 beats/min) and end-exercise body temperature (-0.9 ± 0.5°C) was significantly lower in hypothermic vs. normothermic conditions in both populations (p < 0.05). In pwMS exercise RPE was lower in hypothermic vs. normothermic condition (p = 0.056). No significantly different MRT was found between normothermic vs. hypothermic conditions in both populations. CONCLUSIONS: Lowering body temperature prior to endurance exercise does not affect muscle oxidative capacity in pwMS, but lowers RPE, thus making it possible to prescribe exercises of greater intensity and/or longer duration. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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