The histopathological approach to inflammatory bowel disease: a practice guide.
Inflammatory bowel diseases (IBDs) are lifelong disorders predominantly present in developed countries. In their pathogenesis, an interaction between genetic and environmental factors is involved. This practice guide, prepared on behalf of the European Society of Pathology and the European Crohn's a...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 464; no. 5; pp. 511 - 528 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | practice guidelines Journal Article |
| Publicado: |
Springer Nature
May2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103941983&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103941983 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: May2014 vid: 464 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103941983 NLM24487791 2012570967 10.1007/s00428-014-1543-4 NLM24487791 103941983 ppf: 511 ppct: 17 formats: fmt: @attributes: type: P tig: atl: The histopathological approach to inflammatory bowel disease: a practice guide. aug: au: Langner, Cord Magro, Fernando Driessen, Ann Ensari, Arzu Mantzaris, Gerassimos J Villanacci, Vincenzo Becheanu, Gabriel Borralho Nunes, Paula Cathomas, Gieri Fries, Walter Jouret-Mourin, Anne Mescoli, Claudia de Petris, Giovanni Rubio, Carlos A Shepherd, Neil A Vieth, Michael Eliakim, Rami Geboes, Karel affil: Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria, cord.langner@medunigraz.at. sug: subj: Inflammatory Bowel Diseases Diagnosis ab: Inflammatory bowel diseases (IBDs) are lifelong disorders predominantly present in developed countries. In their pathogenesis, an interaction between genetic and environmental factors is involved. This practice guide, prepared on behalf of the European Society of Pathology and the European Crohn's and Colitis Organisation, intends to provide a thorough basis for the histological evaluation of resection specimens and biopsy samples from patients with ulcerative colitis or Crohn's disease. Histopathologically, these diseases are characterised by the extent and the distribution of mucosal architectural abnormality, the cellularity of the lamina propria and the cell types present, but these features frequently overlap. If a definitive diagnosis is not possible, the term indeterminate colitis is used for resection specimens and the term inflammatory bowel disease unclassified for biopsies. Activity of disease is reflected by neutrophil granulocyte infiltration and epithelial damage. The evolution of the histological features that are useful for diagnosis is time- and disease-activity dependent: early disease and long-standing disease show different microscopic aspects. Likewise, the histopathology of childhood-onset IBD is distinctly different from adult-onset IBD. In the differential diagnosis of severe colitis refractory to immunosuppressive therapy, reactivation of latent cytomegalovirus (CMV) infection should be considered and CMV should be tested for in all patients. Finally, patients with longstanding IBD have an increased risk for the development of adenocarcinoma. Dysplasia is the universally used marker of an increased cancer risk, but inter-observer agreement is poor for the categories low-grade dysplasia and indefinite for dysplasia. A diagnosis of dysplasia should not be made by a single pathologist but needs to be confirmed by a pathologist with expertise in gastrointestinal pathology. pubtype: Academic Journal doctype: practice guidelines Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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