Migration of alloplastic bone graft material in infected conditions: a case study and animal experiment.

Purpose: Distant migration associated with sinus lifting procedures has not been investigated. In the present study, a case of distant migration of graft material was observed, and the potential mechanisms of migration were analyzed using material analysis and in vivo experiments.Materials and Metho...

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Publicado en:Journal of Oral & Maxillofacial Surgery (02782391) Vol. 72; no. 6; pp. 1093.e1 - 10931
Autores principales: Seok, Hyun, Lee, Seuk-Keun, Kim, Seong-Gon, Kang, Tae-Yeon, Lee, Myung-Jin, Chae, Weon-Sik
Formato: case study Journal Article
Publicado: W B Saunders Jun2014
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jun2014
      vid: 72
      iid: 6
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      pub: W B Saunders
      place: Philadelphia, Pennsylvania
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        103943563
        NLM24709514
        2012583645
        10.1016/j.joms.2014.01.021
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        103943563
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      formats:
      tig:
        atl: Migration of alloplastic bone graft material in infected conditions: a case study and animal experiment.
      aug:
        au:
          Seok, Hyun
          Lee, Seuk-Keun
          Kim, Seong-Gon
          Kang, Tae-Yeon
          Lee, Myung-Jin
          Chae, Weon-Sik
        affil: Resident, Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea.
      sug:
        subj:
          Bone Substitutes Adverse Effects
          Foreign-Body Migration Etiology
          Surgery, Oral Adverse Effects
          Animals
          Connective Tissue Pathology
          Models, Biological
          Electron Probe Microanalysis
          Foreign Bodies Pathology
          Granulation Tissue Pathology
          Minerals Adverse Effects
          Minerals
          Lymphadenitis Etiology
          Lymphatic System Pathology
          Male
          Microscopy, Electron, Scanning
          Middle Age
          Particle Size
          Physiochemical Phenomena
          Rats
          Spectrophotometry, Infrared
          Staphylococcal Infections Microbiology
          Connective Tissue Microbiology
          Connective Tissue Surgery
          Submandibular Gland Pathology
          X-Rays
          Middle Aged: 45-64 years
          Male
      ab: Purpose: Distant migration associated with sinus lifting procedures has not been investigated. In the present study, a case of distant migration of graft material was observed, and the potential mechanisms of migration were analyzed using material analysis and in vivo experiments.Materials and Methods: The migrated graft material was biphasic calcium phosphate-based alloplastic material (BCP), and its physical properties were compared with those of xenogenic material (Bio-Oss). The comparisons of the physical properties were performed using scanning electronic microscopic, x-ray diffraction, and Fourier-transform infrared absorbance spectra analysis. The comparative graft migration study was performed using the subcutaneous pocket model in rats (n = 10). The clinical case was analyzed by histologic section and energy dispersive x-ray (EDX) microanalysis.Results: The observed diffraction patterns from the Bio-Oss revealed characteristic diffractions for the hydroxyapatite phase, and those from the BCP revealed additional diffractions that could be assigned to the tricalcium phosphate phase. In the animal model, the graft migration distances observed in the BCP group were significantly greater than those observed in the Bio-Oss group (P = .012). In the clinical case, the lymphatic vessels of the submandibular gland contained foreign materials that were morphologically similar to those of the maxillary sinus. EDX microanalysis revealed that the particles in the lymphatic vessels exhibited calcium concentrations that were approximately 200 times greater than those in the adjacent glandular tissue.Conclusions: In the present study, BCP-based sinus grafts had migrated into the submandibular glandular area by way of the lymphatic chain in the presented clinical case.
      pubtype: Academic Journal
      doctype:
        case study
        Journal Article
      ougenre: Article
    language: English
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