Iron supplementation in infancy contributes to more adaptive behavior at 10 years of age.
Most studies of behavioral/developmental effects of iron deficiency anemia (IDA) or iron supplementation in infancy have found social-emotional differences. Differences could relate to behavioral inhibition or lack of positive affect and altered response to reward. To determine long-term behavioral...
| Published in: | Journal of Nutrition Vol. 144; no. 6; pp. 838 - 846 |
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| Main Authors: | , , , , |
| Format: | research randomized controlled trial Journal Article |
| Published: |
Elsevier B.V.
6/1/2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103947547&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103947547 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00223166 NUI jtl: Journal of Nutrition issn: 00223166 maglogo: N pubinfo: dt: 6/1/2014 vid: 144 iid: 6 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 103947547 NLM24717366 2012589395 10.3945/jn.113.182048 NLM24717366 PMC4018948 103947547 ppf: 838 ppct: 8 formats: tig: atl: Iron supplementation in infancy contributes to more adaptive behavior at 10 years of age. aug: au: Lozoff, Betsy Castillo, Marcela Clark, Katy M Smith, Julia B Sturza, Julie affil: Center for Human Growth and Development and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI blozoff@umich.edu. sug: subj: Adaptation, Psychological Drug Effects Dietary Supplements Emotions Drug Effects Infant Nutritional Physiology Iron Compounds Administration and Dosage Anemia, Iron Deficiency Prevention and Control Child Chile Depression Prevention and Control Depression Psychosocial Factors Double-Blind Studies Emotions Female Prospective Studies Human Infant Male Socioeconomic Factors Child: 6-12 years Infant: 1-23 months Female Male ab: Most studies of behavioral/developmental effects of iron deficiency anemia (IDA) or iron supplementation in infancy have found social-emotional differences. Differences could relate to behavioral inhibition or lack of positive affect and altered response to reward. To determine long-term behavioral effects, the study was a follow-up of a randomized controlled trial of behavioral/developmental effects of preventing IDA in infancy. Healthy Chilean infants free of IDA at age 6 mo were randomly assigned to iron supplementation or no added iron (formula with iron/powdered cow milk, vitamins with/without iron) from ages 6 to 12 mo. At age 10 y, 59% (666 of 1123) and 68% (366 of 534) of iron-supplemented and no-added-iron groups were assessed. Social-emotional outcomes included maternal-reported behavior problems, self-reported behavior, examiner ratings, and video coding of a social stress task and gamelike paradigms. Examiners rated the iron-supplemented group as more cooperative, confident, persistent after failure, coordinated, and direct and reality-oriented in speech and working harder after praise compared with the no-added-iron group. In a task designed to elicit positive affect, supplemented children spent more time laughing and smiling together with their mothers and started smiling more quickly. In the social stress task they smiled and laughed more and needed less prompting to complete the task. All P values were <0.05; effect sizes were 0.14-0.36. There were no differences in behaviors related to behavioral inhibition, such as anxiety/depression or social problems. In sum, iron supplementation in infancy was associated with more adaptive behavior at age 10 y, especially in affect and response to reward, which may improve performance at school and work, mental health, and personal relationships. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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