Computer-Aided Diagnosis of Hyperacute Stroke with Thrombolysis Decision Support Using a Contralateral Comparative Method of CT Image Analysis.

New and improved techniques have been continuously introduced into CT and MR imaging modalities for the diagnosis and therapy planning of acute stroke. Nevertheless, non-contrast CT (NCCT) is almost always used by every institution as the front line diagnostic imaging modality due to its high afford...

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Publicado en:Journal of Digital Imaging Vol. 27; no. 3; pp. 392 - 407
Autores principales: Shieh, Yao, Chang, Chien-Hung, Shieh, Mengkai, Lee, Tsong-Hai, Chang, Yeu, Wong, Ho-Fai, Chin, Shy, Goodwin, Scott
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Jun2014
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Computer-Aided Diagnosis of Hyperacute Stroke with Thrombolysis Decision Support Using a Contralateral Comparative Method of CT Image Analysis.
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          Shieh, Yao
          Chang, Chien-Hung
          Shieh, Mengkai
          Lee, Tsong-Hai
          Chang, Yeu
          Wong, Ho-Fai
          Chin, Shy
          Goodwin, Scott
        affil: Stroke Center and Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Chang Gung University, Kwei-Shan Taiwan 333
      sug:
        subj:
          Stroke Diagnosis
          Radiographic Image Interpretation, Computer-Assisted
          Decision Support Systems, Clinical
          Human
          Tomography, X-Ray Computed
          Female
          Male
          Adult
          Middle Age
          Aged
          Aged, 80 and Over
          Clinical Assessment Tools
          Taiwan
          ROC Curve
          Funding Source
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Female
          Male
      ab: New and improved techniques have been continuously introduced into CT and MR imaging modalities for the diagnosis and therapy planning of acute stroke. Nevertheless, non-contrast CT (NCCT) is almost always used by every institution as the front line diagnostic imaging modality due to its high affordability and availability. Consequently, the potential reward of extracting as much clinical information as possible from NCCT images can be very great. Intravenous tissue plasminogen activator (tPA) has become the gold standard for treating acute ischemic stroke because it is the only acute stroke intervention approved by the FDA. ASPECTS scoring based on NCCT images has been shown to be a reliable scoring method that helps physicians to make sound decisions regarding tPA administration. In order to further reduce inter-observer variation, we have developed the first end-to-end automatic ASPECTS scoring system using a novel method of contralateral comparison. Due to the self-adaptive nature of the method, our system is robust and has good generalizability. ROC analysis based on evaluation of 103 subjects who presented to the stroke center of Chang Gung Memorial Hospital with symptoms of acute stroke has shown that our system's dichromatic classification of patients into thrombolysis indicated or thrombolysis contraindicated groups has achieved a high accuracy rate with AUC equal to 90.2 %. The average processing time for a single case is 170 s. In conclusion, our system has the potential of enhancing quality of care and providing clinical support in the setting of a busy stroke or emergency center.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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