Bringing back the old: time to reevaluate the high-frequency ventilation strategy.
Objective:To examine the role of frequency in high-frequency ventilation (HFV) on carbon-dioxide (CO2) elimination and lung injury, independent of its effect on tidal volume.Study Design:An anatomically representative lung model was attached to a mechanical ventilator capable of providing HFV with a...
| Publicado en: | Journal of Perinatology Vol. 34; no. 6; pp. 464 - 468 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103951768&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103951768 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07438346 DZF jtl: Journal of Perinatology issn: 07438346 maglogo: Y pubinfo: dt: Jun2014 vid: 34 iid: 6 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 103951768 96221321 10.1038/jp.2014.39 NLM24625518 103951768 ppf: 464 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Bringing back the old: time to reevaluate the high-frequency ventilation strategy. aug: au: Mukerji, A Belik, J Sanchez-Luna, M affil: Division of Neonatology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada sug: subj: Respiration, Artificial Methods Human Models, Anatomic In Vitro Studies Two-Way Analysis of Variance Post Hoc Analysis Descriptive Statistics ab: Objective:To examine the role of frequency in high-frequency ventilation (HFV) on carbon-dioxide (CO2) elimination and lung injury, independent of its effect on tidal volume.Study Design:An anatomically representative lung model was attached to a mechanical ventilator capable of providing HFV with a constant volume. CO2 was infused directly into the lung, and a commercially available end-tidal CO2 detector was used to determine CO2 elimination. CO2 elimination and amplitude of pressure transmissions were evaluated using frequencies ranging from 5 to 15 Hz. The pressure-volume index (PVI) was described as the product of the volume and pressures delivered to the lung, a surrogate for lung injury.Result:The use of increasing frequencies directly correlated with improved CO2 clearance when keeping the tidal volume fixed, expressed as percent CO2 remaining in the lung at 25 s (66.5 (±1.1)%, 50.5 (±0.1)% and 37.8 (±0.3)% at 5, 10 and 15 Hz, respectively, P<0.05). With a fixed tidal volume, there was a decrease in pressure amplitudes transmitted to the lung with a decline in the PVI (53.9 (±2.7) mmHg ml−1, 41.1 (±0.9) mmHg ml−1 and 23.4 (±3.6) mmHg ml−1, at 5, 10 and 15 Hz, respectively, P<0.05).Conclusion:Frequency has a direct relationship with CO2 elimination when tidal volume is fixed. Using low delivered tidal volumes and high frequencies may allow for improved ventilation efficacy, while minimizing lung injury. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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