Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla.
Objectives: The purpose of this study was to evaluate the usefulness of Gd-EOB-DTPA-enhanced 3-T MRI to determine the hepatic functional reserve expressed by the model for end-stage liver disease (MELD) score.Methods: A total of 121 patients with normal liver function (NLF; MELD score ≤ 10) and 29 p...
| Publicado en: | European Radiology Vol. 24; no. 5; pp. 1013 - 1020 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
May2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103954597&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103954597 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2014 vid: 24 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103954597 NLM24531844 2012606247 10.1007/s00330-014-3108-y NLM24531844 103954597 ppf: 1013 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Assessing liver function by liver enhancement during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MRI at 3 Tesla. aug: au: Verloh, N Haimerl, M Zeman, F Schlabeck, M Barreiros, A Loss, M Schreyer, A G Stroszczynski, C Fellner, C Wiggermann, P affil: Department of Radiology, University Hospital Regensburg, 93042, Regensburg, Germany, niklas.verloh@stud.uni-regensburg.de. sug: subj: Contrast Media Diagnostic Use Liver Diseases Diagnosis Liver Function Tests Methods Magnetic Resonance Imaging Methods Adult Aged Liver Failure Diagnosis Liver Failure Pathology Liver Failure Physiopathology Evaluation Research Female Epithelial Cells Pathology Human Liver Diseases Pathology Liver Diseases Physiopathology Male Middle Age Prospective Studies Severity of Illness Indices Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: The purpose of this study was to evaluate the usefulness of Gd-EOB-DTPA-enhanced 3-T MRI to determine the hepatic functional reserve expressed by the model for end-stage liver disease (MELD) score.Methods: A total of 121 patients with normal liver function (NLF; MELD score ≤ 10) and 29 patients with impaired liver function (ILF; MELD score > 10) underwent contrast-enhanced MRI with a hepatocyte-specific contrast agent at 3T. T1-weighted volume interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before and 20 min after contrast injection. Relative enhancement (RE) between plain signal intensity and contrast-enhanced signal intensity was calculated and was used to determine Gd-EOB-DTPA uptake into the liver parenchyma for patients with different MELD scores.Results: RE differed significantly (p ≤ 0.001) between patients with NLF (87.2 ± 29.5 %) and patients with ILF (45.4 ± 26.5 %). The optimal cut-off value for RE to differentiate NLF from ILF was 47.7 % (AUC 0.87). This cut-off value showed a sensitivity of 82.8 % and a specificity of 92.7 % for the differentiation of the analysed groups.Conclusion: Gd-EOB-DTPA uptake in hepatocytes is strongly affected by liver function. Gd-EOB-DTPA-enhanced MRI and assessment of RE during the hepatobiliary phase (HBP) may serve as a useful image-based test in liver imaging for determining regional and global liver function.Key Points: Hepatic uptake of Gd-EOB-DTPA is strongly affected by liver function. Relative enhancement during HBP in GD-EOB-DTPA MRI correlates with the MELD score. Assessment of relative enhancement may help improve treatment in routine clinical practice. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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