Ventilatory Response to Carbon Dioxide Output in Subjects With Congestive Heart Failure and in Patients with COPD With Comparable Exercise Capacity.
BACKGROUND: Patients with congestive heart failure or COPD may share an increased response in minute ventilation (V̇E) to carbon dioxide output (V̇CO2) during exercise. The goal of this study was to ascertain whether the V̇E/V̇CO2 slope and V̇E/V̇CO2 intercept can discriminate between subjects with...
| Publicado en: | Respiratory Care Vol. 59; no. 7; pp. 1034 - 1042 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jul2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103969187&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103969187 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Jul2014 vid: 59 iid: 7 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 103969187 96866606 10.4187/respcare.02629 NLM24046458 103969187 ppf: 1034 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Ventilatory Response to Carbon Dioxide Output in Subjects With Congestive Heart Failure and in Patients with COPD With Comparable Exercise Capacity. aug: au: Teopompi, Elisabetta Tzani, Panagiota Aiello, Marina Ramponi, Sara Visca, Dina Gioia, Maria Rosaria Marangio, Emilio Serra, Walter Chetta, Alfredo affil: Respiratory Disease and Lung Function Unit, University Hospital, Parma, Italy sug: subj: Carbon Dioxide Physiology Heart Failure Physiopathology Respiration, Artificial Evaluation Pulmonary Disease, Chronic Obstructive Physiopathology Treatment Outcomes Exercise Test, Cardiopulmonary Evaluation Human Male Female Aged Middle Age Descriptive Statistics Models, Statistical Pearson's Correlation Coefficient Linear Regression Unpaired T-Tests Chi Square Test Aged: 65+ years Middle Aged: 45-64 years Male Female ab: BACKGROUND: Patients with congestive heart failure or COPD may share an increased response in minute ventilation (V̇E) to carbon dioxide output (V̇CO2) during exercise. The goal of this study was to ascertain whether the V̇E/V̇CO2 slope and V̇E/V̇CO2 intercept can discriminate between subjects with congestive heart failure and those with COPD at equal peak oxygen uptake (V̇O2). METHODS: We studied 46 subjects with congestive heart failure (mean age 61 ± 9 y) and 46 subjects with COPD (mean age 64 ± 8 y) who performed a cardiopulmonary exercise test. RESULTS: The V̇E/V̇CO2 slope was significantly higher in subjects with congestive heart failure compared with those with COPD (39.5 ± 9.5 vs 31.8 ± 7.4, P < .01) at peak V̇O2 < 16 mL/kg/min, but not ≥ 16 mL/kg/min (28.3 ± 5.3 vs 28.9 ± 6.6). The V̇E/V̇CO2 intercept was significantly higher in both subgroups of subjects with COPD compared with the corresponding values in the subjects with congestive heart failure (3.60 ± 1.7 vs -0.16 ± 1.7 L/min, P < .01; 3.63 ± 2.7 vs 0.87 ± 1.5 L/min, P < .01). According to receiver operating characteristic curve analysis, when all subjects with peak V̇O2 < 16 mL/kg/min were considered, subjects with COPD had a higher likelihood to have the V̇E/V̇CO2 intercept > 2.14 L/min (0.92 sensitivity, 0.96 specificity). Regardless of peak V̇O2, the end-tidal pressure of CO2 (PETCO2) at Peak exercise was not different in subjects with congestive heart failure (P = .42) and was significantly higher in subjects with COPD (P < .01) compared with the corresponding unloaded PETCO2. CONCLUSIONS: The ventilatory response to V̇O2 during exercise was significantly different between subjects with congestive heart failure and those with COPD in terms of the V̇E/V̇CO2 slope with moderate-to-severe reduction in exercise capacity and in terms of the V̇E/V̇CO2 intercept regardless of exercise capacity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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