Supplementation with olive oil, but not fish oil, improves cutaneous wound healing in stressed mice.
Supplementation with olive and fish oils reverses the effects of stress on behavioral activities and adrenal activation. However, previous studies have not shown whether supplementation with olive and fish oil could inhibit the effects of stress on cutaneous wound healing. Thus, this study investiga...
| Publicado en: | Wound Repair & Regeneration Vol. 22; no. 4; pp. 537 - 548 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul/Aug2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103977704&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103977704 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Jul/Aug2014 vid: 22 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103977704 97119516 10.1111/wrr.12191 NLM25041622 103977704 ppf: 537 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Supplementation with olive oil, but not fish oil, improves cutaneous wound healing in stressed mice. aug: au: Rosa, Alice dos Santos Bandeira, Luana Graziella Monte-Alto-Costa, Andréa Romana-Souza, Bruna affil: Department of Animal Biology, Rural Federal University of Rio de Janeiro sug: subj: Skin Wound Healing Dietary Supplements Olive Oil Fish Oils Animal Studies Mice Models, Biological Stress Immunohistochemistry Microscopy Immunoblotting Tissue Culture Techniques Descriptive Statistics Two-Way Analysis of Variance Post Hoc Analysis Data Analysis Software Funding Source ab: Supplementation with olive and fish oils reverses the effects of stress on behavioral activities and adrenal activation. However, previous studies have not shown whether supplementation with olive and fish oil could inhibit the effects of stress on cutaneous wound healing. Thus, this study investigated the effects of supplementation with fish or olive oil on cutaneous healing in stressed mice. Mice were subjected to rotational stress and treated with olive or fish oil daily until euthanasia. An excisional lesion was created on each mouse, and 14 days later, the lesions were analyzed. In addition, murine skin fibroblasts were exposed to elevated epinephrine levels plus olive oil, and fibroblast activity was evaluated. In the in vivo studies, administration of olive oil, but not fish oil, inhibited stress-induced reduction in wound contraction, reepithelialization, hydroxyproline levels, and blood vessel density. Stress-induced increases in vascular endothelial growth factor expression and the numbers of macrophages and neutrophils were reversed only by olive oil. Both oils reversed stress-induced increase in catecholamine levels and oxidative damage. In in vitro studies, olive oil treatment reversed the reduction in fibroblast migration and collagen deposition and the increase in lipid peroxidation induced by epinephrine. In conclusion, supplementation with olive oil, but not fish oil, improves cutaneous wound healing in chronically stressed mice. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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