Nickel free-diet enhances the Helicobacter pylori eradication rate: a pilot study.
Background: The Helicobacter pylori eradication rate with standard triple therapy is very low. H. pylori is known to require the nickel-containing metalloenzymes urease and NiFe-hydrogenase to survive at the low pH environment in the stomach.Aim: To compare the H. pylori eradication rate of a nickel...
| Publicado en: | Digestive Diseases & Sciences Vol. 59; no. 8; pp. 1851 - 1856 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Aug2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103979426&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103979426 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01632116 1VP jtl: Digestive Diseases & Sciences issn: 01632116 maglogo: N pubinfo: dt: Aug2014 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103979426 NLM24595654 2012668435 10.1007/s10620-014-3060-3 NLM24595654 103979426 ppf: 1851 ppct: 5 formats: tig: atl: Nickel free-diet enhances the Helicobacter pylori eradication rate: a pilot study. aug: au: Campanale, M Nucera, E Ojetti, V Cesario, V Di Rienzo, T A D'Angelo, G Pecere, S Barbaro, F Gigante, G De Pasquale, T Rizzi, A Cammarota, G Schiavino, D Franceschi, F Gasbarrini, A affil: Internal Medicine and Endoscopy, Gemelli Hospital, Largo A. Gemelli, 8, 00168, Rome, Italy, chiaracampanale@hotmail.com. sug: subj: Helicobacter Infections Diet Therapy Helicobacter Infections Drug Therapy Helicobacter Pylori Drug Effects Nickel Contraindications Adult Amoxicillin Therapeutic Use Antibiotics Therapeutic Use Gastrointestinal Agents Therapeutic Use Clarithromycin Therapeutic Use Drug Therapy, Combination Female Human Lansoprazole Therapeutic Use Male Pilot Studies Adult: 19-44 years Female Male ab: Background: The Helicobacter pylori eradication rate with standard triple therapy is very low. H. pylori is known to require the nickel-containing metalloenzymes urease and NiFe-hydrogenase to survive at the low pH environment in the stomach.Aim: To compare the H. pylori eradication rate of a nickel free-diet associated with standard triple therapy and standard triple therapy alone as the first-line regimen.Methods: Fifty-two sex- and age-matched patients at the first diagnosis of H. pylori infection were randomized 1:1 into two different therapeutic schemes: (1) standard LCA (26 patients): lansoprazole 15 mg bid, clarithromycin 500 mg bid and amoxicillin 1,000 mg bid for 7 days with a common diet; (2) standard LCA plus a nickel free-diet (NFD-LCA) (26 patients). Patients followed 30 days of a nickel-free diet plus a week of lansoprazole 15 mg bid, clarithromycin 500 mg bid and amoxicillin 1,000 mg bid starting from day 15 of the diet.Results: All patients completed the study. A significantly higher eradication rate was observed in the NFD-LCA group (22/26) versus LCA group (12/26) (p < 0.01). Only a few patients (9 of 52) reported the occurrence of mild therapy-related side effects, without any significant differences between the two groups.Conclusions: The addition of a nickel-free diet to standard triple therapy significantly increases the H. pylori eradication rate. The reduction of H. pylori urease activity due to the nickel-free diet could expose the bacterium to gastric acid and increase H. pylori's susceptibility to amoxicillin. Further studies are necessary to confirm this preliminary result. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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