Alterations in brain structure related to breast cancer and its treatment: chemotherapy and other considerations.
Cognitive effects of cancer and its treatment have been a topic of increasing investigation over the past ~30 years. Recent studies have focused on better understanding the neural correlates of these effects, with an emphasis on post-chemotherapy effects in breast cancer patients. Structural MRI stu...
| Publicado en: | Brain Imaging & Behavior Vol. 7; no. 4; pp. 374 - 388 |
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| Autores principales: | , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103995577&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103995577 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2013 vid: 7 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103995577 NLM23996156 2012430653 10.1007/s11682-013-9256-x NLM23996156 PMC3869865 103995577 ppf: 374 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Alterations in brain structure related to breast cancer and its treatment: chemotherapy and other considerations. aug: au: McDonald, Brenna C Saykin, Andrew J affil: Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA, mcdonalb@iupui.edu. sug: subj: Antineoplastic Agents Adverse Effects Brain Drug Effects Brain Pathology Breast Neoplasms Drug Therapy Breast Neoplasms Pathology Magnetic Resonance Imaging Methods Medical Practice, Evidence-Based Female Human Female ab: Cognitive effects of cancer and its treatment have been a topic of increasing investigation over the past ~30 years. Recent studies have focused on better understanding the neural correlates of these effects, with an emphasis on post-chemotherapy effects in breast cancer patients. Structural MRI studies have utilized both automated and manual approaches to quantify gray and white matter characteristics (e.g., regional volume and density) in breast cancer patients treated with chemotherapy relative to patients who did not receive chemotherapy and/or healthy controls. While most work to date has been retrospective, a small number of baseline (pre-systemic therapy) and prospective longitudinal studies have been conducted. Data have consistently shown lower gray and white matter volume and density in patients treated with chemotherapy, particularly in frontal and temporal brain regions. Host factors and/or the cancer disease process and other therapies (e.g., antiestrogen treatment) also seem likely to contribute to the observed differences, though the relative contributions of these effects have not yet been investigated in detail. These structural abnormalities have been shown to relate to subjective and objective cognitive functioning, as well as to biological factors that may help to elucidate the underlying mechanism(s). This review examines the currently available published observations and discusses the major themes and promising directions for future studies. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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