Potential effects of medicinal plants and secondary metabolites on acute lung injury.
Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. ALI is characterized by increased permeability of the alveolar-capillary membrane, edema, uncontrolled neutrophils migration to the lung, and diffuse alveolar damage, leading to acute hypoxemic...
| Publicado en: | BioMed Research International Vol. 2013; pp. 576479 - 576480 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103995796&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103995796 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103995796 2012431107 NLM24224172 PMC3810192 103995796 ppf: 576479 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Potential effects of medicinal plants and secondary metabolites on acute lung injury. aug: au: Favarin, Daniely Cornélio de Oliveira, Jhony Robison de Oliveira, Carlo Jose Freire Rogerio, Alexandre de Paula affil: Departamento de Clínica Médica, Laboratório de ImunoFarmacologia Experimental, Instituto de Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Rua Manoel Carlos 162, 38025-380 Uberaba, MG, Brazil. sug: subj: Acute Lung Injury Drug Therapy Flavonoids Analogs and Derivatives Plant Extracts Therapeutic Use Plants, Medicinal Metabolism Acute Lung Injury Pathology Adrenal Cortex Hormones Adverse Effects Capillary Permeability Drug Effects Flavonoids Flavonoids Therapeutic Use Ginkgo Biloba Ginkgo Biloba Metabolism Lung Drug Effects Lung Pathology Plant Extracts Metabolism Plants, Medicinal Metabolic Networks and Pathways ab: Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. ALI is characterized by increased permeability of the alveolar-capillary membrane, edema, uncontrolled neutrophils migration to the lung, and diffuse alveolar damage, leading to acute hypoxemic respiratory failure. Although corticosteroids remain the mainstay of ALI treatment, they cause significant side effects. Agents of natural origin, such as medicinal plants and their secondary metabolites, mainly those with very few side effects, could be excellent alternatives for ALI treatment. Several studies, including our own, have demonstrated that plant extracts and/or secondary metabolites isolated from them reduce most ALI phenotypes in experimental animal models, including neutrophil recruitment to the lung, the production of pro-inflammatory cytokines and chemokines, edema, and vascular permeability. In this review, we summarized these studies and described the anti-inflammatory activity of various plant extracts, such as Ginkgo biloba and Punica granatum, and such secondary metabolites as epigallocatechin-3-gallate and ellagic acid. In addition, we highlight the medical potential of these extracts and plant-derived compounds for treating of ALI. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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