Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B.
Objectives: We measured the accuracy of magnetic resonance elastography (MRE) for the detection and staging of liver fibrosis in chronic hepatitis B (CHB) and compared it with serum fibrosis markers.Methods: Prospective comparison of MRE and routine serum fibrosis markers, namely serum alanine amino...
| Publicado en: | European Radiology Vol. 24; no. 1; pp. 70 - 79 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103997874&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103997874 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2014 vid: 24 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103997874 NLM23928932 2012436902 10.1007/s00330-013-2978-8 NLM23928932 103997874 ppf: 70 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B. aug: au: Venkatesh, Sudhakar Kundapur Wang, Gang Lim, Seng Gee Wee, Aileen affil: Department of Radiology, National University Health System, 5, Lower Kent Ridge Road, Singapore, Singapore, venkatesh.sudhakar@mayo.edu. sug: subj: Ultrasonography Methods Hepatitis B, Chronic Complications Liver Pathology Liver Cirrhosis Diagnosis Adult Biological Markers Blood Diagnosis, Differential Disease Progression Elasticity Female Prospective Studies Hepatitis B, Chronic Blood Hepatitis B, Chronic Diagnosis Human Liver Physiopathology Liver Cirrhosis Blood Liver Cirrhosis Etiology Male Middle Age Reproducibility of Results Severity of Illness Indices Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: We measured the accuracy of magnetic resonance elastography (MRE) for the detection and staging of liver fibrosis in chronic hepatitis B (CHB) and compared it with serum fibrosis markers.Methods: Prospective comparison of MRE and routine serum fibrosis markers, namely serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), ALT/AST ratio (AAR), AST to platelet ratio index (APRI) and prothrombin index (PI), was performed in 63 consecutive CHB patients who underwent MRE and histological confirmation of liver fibrosis within a 6-month interval. Diagnostic performance of MRE and serum markers for staging fibrosis (≥F1), significant fibrosis (≥F2), advanced fibrosis (≥F3) and cirrhosis (F4) was compared.Results: The study group comprised 63 patients (19 female; mean age ± SD, 50 ± 11.9 years). MRE (ρ = 0.94, P < 0.0001), APRI (ρ = 0.42, P = 0.0006), PI (ρ = 0.42, P = 0.0006) and AST (ρ = 0.28, P = 0.028) results correlated significantly with fibrosis stage. MRE was significantly more accurate than serum fibrosis markers for the detection of significant fibrosis (0.99 vs. 0.55-0.73) and cirrhosis (0.98 vs. 0.53-0.77). Sensitivity, specificity, positive predictive and negative predictive values for MRE for significant fibrosis and cirrhosis were 97.4 %, 100 %, 100 % and 96 %, and 100 %, 95.2 %, 91.3 % and 100 %, respectively.Conclusion: MRE is an accurate non-invasive technique for the detection and staging of liver fibrosis in CHB.Key Points: • Magnetic resonance elastography is accurate for liver fibrosis detection and staging. • MR elastography is more accurate than serum tests for staging liver fibrosis. • MR elastography can potentially replace liver biopsy in chronic hepatitis B. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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