Q-elastosonography of solid thyroid nodules: assessment of diagnostic efficacy and interobserver variability in a large patient cohort.
Objective: Evaluation of the diagnostic efficacy and interobserver agreement of Q-elastography in the differentiation of benign from malignant thyroid nodules.Methods: A total of 344 thyroid nodules in 288 patients were examined with grey-scale and colour Doppler ultrasound (CDUS) and Q-elastography...
| Published in: | European Radiology Vol. 24; no. 1; pp. 143 - 151 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Jan2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103997882&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103997882 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jan2014 vid: 24 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103997882 NLM23979108 2012436910 10.1007/s00330-013-2991-y NLM23979108 103997882 ppf: 143 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Q-elastosonography of solid thyroid nodules: assessment of diagnostic efficacy and interobserver variability in a large patient cohort. aug: au: Cantisani, Vito Grazhdani, Hektor Ricci, Paolo Mortele, Koenraad Di Segni, Mattia D'Andrea, Vito Redler, Adriano Di Rocco, Giorgio Giacomelli, Laura Maggini, Elena Chiesa, Carlo Erturk, Sukru Mehmet Sorrenti, Salvatore Catalano, Carlo D'Ambrosio, Ferdinando affil: Department of Radiology, Oncology, and Anatomy Pathology, University 'La Sapienza', Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy, vito.cantisani@uniroma1.it. sug: subj: Calcinosis Ultrasonography Ultrasonography Methods Thyroid Neoplasms Ultrasonography Adolescence Adult Aged Aged, 80 and Over Diagnosis, Differential Female Prospective Studies Human Male Middle Age ROC Curve Reproducibility of Results Ultrasonography, Doppler, Color Methods Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objective: Evaluation of the diagnostic efficacy and interobserver agreement of Q-elastography in the differentiation of benign from malignant thyroid nodules.Methods: A total of 344 thyroid nodules in 288 patients were examined with grey-scale and colour Doppler ultrasound (CDUS) and Q-elastography by two independent operators. Nodules with hypoechogenicity, poorly defined margins, microcalcifications, and intralesional vascularity were classified as suspicious. Diagnostic performances of CDUS features and Q-elastography for predicting thyroid malignancy were estimated using ROC analysis. Cytology or histopathology was the reference standard. Interobserver agreement in the evaluation of CDUS and Q-elastography was assessed using Cohen's k-statistic.Results: Q-elastography showed excellent diagnostic performance for the prediction of thyroid malignancy, with sensitivity of 93 % and specificity of 92 % for operator 1 (best cutoff at 2.02), and sensitivity of 84 % and specificity of 79 % for operator 2 (best cutoff at 1.86). Performance of Q-elastography was superior to that of CDUS. Reproducibility of the findings was excellent for both Q-elastography and CDUS features as assessed with Cohen's k, which was highest for strain ratio measurements (0.95) and lowest for the echogenicity score (0.83).Conclusions: Q-elastography showed excellent performance. It is a valid and reproducible diagnostic method as well as a promising tool for identifying suspicious solid thyroid nodules needing cytological assessment and surgery.Key Points: • Elastography is an additional tool for optimal characterisation of malignant thyroid nodules. • The use of semiquantitative elastographic evaluation increases the diagnostic performance, • The interobserver agreement of quantitative elastography can be considered to be good. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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