Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis.

Background: The Cryptococcus neoformans polysaccharide capsule is a well-characterized virulence factor with immunomodulatory properties. The organism and/or shed capsule is postulated to raise intracranial pressure (ICP) in cryptococcal meningitis (CM) by mechanical obstruction of cerebrospinal flu...

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Bibliographic Details

Published in:	Journal of Infectious Diseases Vol. 209; no. 1; pp. 74 - 83
Main Authors:	Robertson, Emma J, Najjuka, Grace, Rolfes, Melissa A, Akampurira, Andrew, Jain, Neena, Anantharanjit, Janani, von Hohenberg, Maximilian, Tassieri, Manlio, Carlsson, Allan, Meya, David B, Harrison, Thomas S, Fries, Bettina C, Boulware, David R, Bicanic, Tihana
Format:	research Journal Article
Published:	Oxford University Press / USA Jan2014
Online Access:	View this record in EBSCOhost