Contrast-enhanced MRI compared with the physical examination in the evaluation of disease activity in juvenile idiopathic arthritis.
Objectives: To assess the value of magnetic resonance imaging (MRI) in discriminating between active and inactive juvenile idiopathic arthritis (JIA) patients and to compare physical examination outcomes with MRI outcomes in the assessment of disease status in JIA patients.Methods: Consecutive JIA p...
| Publicado en: | European Radiology Vol. 24; no. 2; pp. 327 - 335 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2014
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104003751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104003751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2014 vid: 24 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104003751 NLM24101236 2012446284 10.1007/s00330-013-3036-2 NLM24101236 104003751 ppf: 327 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Contrast-enhanced MRI compared with the physical examination in the evaluation of disease activity in juvenile idiopathic arthritis. aug: au: Hemke, Robert Maas, Mario van Veenendaal, Mira Dolman, Koert M van Rossum, Marion A J van den Berg, J Merlijn Kuijpers, Taco W affil: Department of Radiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands, r.hemke@amc.nl. sug: subj: Arthritis, Juvenile Rheumatoid Diagnosis Contrast Media Diagnostic Use Knee Joint Pathology Magnetic Resonance Imaging Methods Physical Examination Methods Adolescence Child Child, Preschool Diagnosis, Differential Female Prospective Studies Human Male ROC Curve Reproducibility of Results Retrospective Design Severity of Illness Indices Adolescent: 13-18 years Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Objectives: To assess the value of magnetic resonance imaging (MRI) in discriminating between active and inactive juvenile idiopathic arthritis (JIA) patients and to compare physical examination outcomes with MRI outcomes in the assessment of disease status in JIA patients.Methods: Consecutive JIA patients with knee involvement were prospectively studied using an open-bore MRI. Imaging findings from 146 JIA patients were analysed (59.6% female; mean age, 12.9 years). Patients were classified as clinically active or inactive. MRI features were evaluated using the JAMRIS system, comprising validated scores for synovial hypertrophy, bone marrow oedema, cartilage lesions and bone erosions.Results: Inter-reader reliability was good for all MRI features (intra-class correlation coefficient [ICC] = 0.87-0.94). No differences were found between the two groups regarding MRI scores of bone marrow oedema, cartilage lesions or bone erosions. Synovial hypertrophy scores differed significantly between groups (P = 0.016). Nonetheless, synovial hypertrophy was also present in 14 JIA patients (35.9%) with clinically inactive disease. Of JIA patients considered clinically active, 48.6% showed no signs of MRI-based synovitis.Conclusions: MRI can discriminate between clinically active and inactive JIA patients. However, physical examination is neither very sensitive nor specific in evaluating JIA disease activity compared with MRI. Subclinical synovitis was present in >35% of presumed clinically inactive patients.Key Points: • MRI is sensitive for evaluating juvenile idiopathic arthritis (JIA) disease activity. • Contrast-enhanced MRI can distinguish clinically active and inactive JIA patients. • Subclinical synovitis is present in 35.9 % of presumed clinically inactive patients. • Physical examination is neither sensitive nor specific in evaluating JIA disease activity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|