CSF dynamic analysis of a predictive pulsatility-based infusion test for normal pressure hydrocephalus.
Disturbed cerebrospinal fluid (CSF) dynamics are part of the pathophysiology of normal pressure hydrocephalus (NPH) and can be modified and treated with shunt surgery. This study investigated the contribution of established CSF dynamic parameters to AMP(mean), a prognostic variable defined as mean a...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 52; no. 1; pp. 75 - 86 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104003924&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104003924 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jan2014 vid: 52 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104003924 NLM24151060 2012446591 10.1007/s11517-013-1110-1 NLM24151060 104003924 ppf: 75 ppct: 11 formats: fmt: @attributes: type: P tig: atl: CSF dynamic analysis of a predictive pulsatility-based infusion test for normal pressure hydrocephalus. aug: au: Qvarlander, Sara Malm, Jan Eklund, Anders affil: Department of Radiation Sciences - Biomedical Engineering, Umeå University, Umeå, Sweden, sara.qvarlander@radfys.umu.se. sug: subj: Cerebrospinal Fluid Physiology Intracranial Pressure Physiology Hydrocephalus, Normal Pressure Cerebrospinal Fluid Hydrocephalus, Normal Pressure Physiopathology Infusions, Parenteral Methods Cerebrospinal Fluid Shunts Methods Human Models, Theoretical ab: Disturbed cerebrospinal fluid (CSF) dynamics are part of the pathophysiology of normal pressure hydrocephalus (NPH) and can be modified and treated with shunt surgery. This study investigated the contribution of established CSF dynamic parameters to AMP(mean), a prognostic variable defined as mean amplitude of cardiac-related intracranial pressure pulsations during 10 min of lumbar constant infusion, with the aim of clarifying the physiological interpretation of the variable. AMP(mean) and CSF dynamic parameters were determined from infusion tests performed on 18 patients with suspected NPH. Using a mathematical model of CSF dynamics, an expression for AMP(mean) was derived and the influence of the different parameters was assessed. There was high correlation between modelled and measured AMP(mean) (r = 0.98, p < 0.01). Outflow resistance and three parameters relating to compliance were identified from the model. Correlation analysis of patient data confirmed the effect of the parameters on AMP(mean) (Spearman's ρ = 0.58-0.88, p < 0.05). Simulated variations of ±1 standard deviation (SD) of the parameters resulted in AMP(mean) changes of 0.6-2.9 SD, with the elastance coefficient showing the strongest influence. Parameters relating to compliance showed the largest contribution to AMP(mean), which supports the importance of the compliance aspect of CSF dynamics for the understanding of the pathophysiology of NPH. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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