Methodological considerations in quantification of 3'-deoxy-3'-[18F]fluorothymidine uptake measured with positron emission tomography in patients with non-small cell lung cancer.
Purpose: To investigate the effect of image-derived input functions (IDIF), input function corrections and volume of interest (VOI) size in quantification of [(18)F]FLT uptake in non-small cell lung cancer (NSCLC) patients.Procedures: Twenty-three NSCLC patients were scanned on a HR+ scanner. IDIFs...
| Publicado en: | Molecular Imaging & Biology Vol. 16; no. 1; pp. 136 - 146 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104004276&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104004276 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Feb2014 vid: 16 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104004276 104004276 NLM23813332 2012447057 10.1007/s11307-013-0658-3 NLM23813332 104004276 ppf: 136 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Methodological considerations in quantification of 3'-deoxy-3'-[18F]fluorothymidine uptake measured with positron emission tomography in patients with non-small cell lung cancer. aug: au: Frings, Virginie de Langen, Adrianus J Yaqub, Maqsood Schuit, Robert C van der Veldt, Astrid A M Hoekstra, Otto S Smit, Egbert F Boellaard, Ronald affil: Department of Radiology & Nuclear Medicine, VU University Medical Center (VUmc), P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. sug: subj: Carcinoma, Non-Small-Cell Lung Radiography Deoxyribonucleosides Pharmacokinetics Lung Neoplasms Radiography Tomography, Emission-Computed Methods Adult Aged Calibration Carcinoma, Non-Small-Cell Lung Blood Chaos Theory Demography Deoxyribonucleosides Blood Female Human Lung Neoplasms Blood Male Middle Age Regression Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: To investigate the effect of image-derived input functions (IDIF), input function corrections and volume of interest (VOI) size in quantification of [(18)F]FLT uptake in non-small cell lung cancer (NSCLC) patients.Procedures: Twenty-three NSCLC patients were scanned on a HR+ scanner. IDIFs were defined over the aorta and left ventricle. Activity concentration and metabolite fraction were measured in venous blood samples. Venous blood samples at 30, 40 and 60 min after injection were used to calibrate the IDIF time-activity curves. Adaptive thresholds were used for VOI definition. Full kinetic analysis and simplified measures were performed.Results: Non-linear regression analysis showed better fits for the irreversible model compared to the reversible model in the majority. Calibrated and metabolite corrected plus plasma-to-blood ratio corrected input function resulted in high correlations between SUV and Patlak K i (Pearson correlation coefficients 0.86-0.96, p value < 0.001). No significant differences in correlation between SUV and Patlak K i were observed with variation of IDIF structure or VOI size.Conclusions: Plasma-to-blood ratio correction, metabolite correction and calibration improved the correlation between SUV and Patlak K i significantly, indicating the need for these corrections when K i is used to validate semi-quantitative measures, such as SUV. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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