Urease inhibitory constituents from Daphne retusa.
The bioassay-guided fractionation ofDaphne retusaHemsl. has led to the isolation of a new aryl tetrahydronaphthalene lignan derivative named as daphnretusic acid (1), along with six new source compounds such as 5,7-dihydroxyflavone (2), 7-hydroxyflavone (3), 6-methoxyflavone (4), (+) pinoresinol (5)...
| Publicado en: | Journal of Asian Natural Products Research Vol. 16; no. 2; pp. 210 - 216 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104005081&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104005081 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10286020 J40 jtl: Journal of Asian Natural Products Research issn: 10286020 maglogo: Y pubinfo: dt: Feb2014 vid: 16 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104005081 93798060 10.1080/10286020.2013.837457 NLM24266421 104005081 ppf: 210 ppct: 6 formats: tig: atl: Urease inhibitory constituents from Daphne retusa. aug: au: Mansoor, Farrukh Anis, Itrat Khan, Ajmal Marasini, Bishnu P. Choudhary, Muhammad Iqbal Shah, Muhammad Raza affil: Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan sug: subj: Urease Antagonists and Inhibitors Plant Extracts Analysis Plant Extracts Administration and Dosage Lignans Administration and Dosage Flavonoids Administration and Dosage Peptide Hydrolases Drug Effects Molecular Structure Magnetic Resonance Spectroscopy Mass Spectrometry Descriptive Statistics Spectrophotometry, Infrared Biological Assay Chemistry, Pharmaceutical Data Analysis Software Funding Source ab: The bioassay-guided fractionation ofDaphne retusaHemsl. has led to the isolation of a new aryl tetrahydronaphthalene lignan derivative named as daphnretusic acid (1), along with six new source compounds such as 5,7-dihydroxyflavone (2), 7-hydroxyflavone (3), 6-methoxyflavone (4), (+) pinoresinol (5), (+) sesamin (6), and β-sitosterol-3-O-β-D-glucopyranoside (7). Their structures were elucidated by1H NMR,13C NMR, 1D, 2D NMR, UV, IR, and EIMS analyses. All the fractions (n-hexane, CHCl3, AcOEt, CH3OH, and water) and pure compounds (1–7) were subjected to the assay of urease and α-chymotrypsin inhibitory activities. Chloroform and methanol soluble fractions showed moderate urease inhibition. Compound2exhibited significant urease inhibition with IC50value 60.4 ± 0.72 μM, whereas compounds1and3–7remained inactive during urease inhibition and α-chymotrypsin bioassays. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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