The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder.
The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girl...
| Published in: | Journal of Autism & Developmental Disorders Vol. 44; no. 2; pp. 310 - 321 |
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| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Feb2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104006250&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104006250 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Feb2014 vid: 44 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104006250 93922142 10.1007/s10803-013-1860-5 NLM23824705 104006250 ppf: 310 ppct: 11 formats: fmt: @attributes: type: P tig: atl: The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder. aug: au: Rijn, Sophie Stockmann, Lex Borghgraef, Martine Bruining, Hilgo Ravenswaaij-Arts, Conny Govaerts, Lutgarde Hansson, Kerstin Swaab, Hanna affil: Center for Human Genetics, University Hospital of Leuven, Herestraat 49 3000 Leuven Belgium sug: subj: Phenotype Evaluation Klinefelter's Syndrome Symptoms Autism Spectrum Disorder Symptoms Sex Chromosome Disorders Symptoms Social Anxiety Disorders Familial and Genetic Human Funding Source Male Female Comparative Studies Clinical Assessment Tools Scales Child Adolescence Netherlands Child Behavior Checklist Checklists Chi Square Test Post Hoc Analysis Internal Consistency Data Analysis Software Multivariate Analysis of Covariance Analysis of Variance Descriptive Statistics Child: 6-12 years Adolescent: 13-18 years Male Female ab: The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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