The biology of malignant breast tumors has an impact on the presentation in ultrasound: an analysis of 315 cases.
Background: The aim of this study was to evaluate the relation of some ultrasound morphological parameters to biological characteristics in breast carcinoma.Methods: Ultrasound data from 315 breast masses were collected. We analyzed the ultrasound features of the tumors according to the ACR BI-RADS®...
| Publicado en: | BMC Women's Health Vol. 13; no. 1; pp. 47 - 48 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104008649&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104008649 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726874 1CIP jtl: BMC Women's Health issn: 14726874 maglogo: N pubinfo: dt: 2013 vid: 13 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 104008649 104008649 NLM24252758 2012451196 10.1186/1472-6874-13-47 NLM24252758 PMC3840587 104008649 ppf: 47 ppct: 1 formats: fmt: @attributes: type: P tig: atl: The biology of malignant breast tumors has an impact on the presentation in ultrasound: an analysis of 315 cases. aug: au: Wojcinski, S Stefanidou, N Hillemanns, P Degenhardt, F affil: Department for Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany. s@wojcinski.de. sug: subj: Breast Neoplasms Ultrasonography Carcinoma, Ductal, Breast Ultrasonography Carcinoma, Lobular Ultrasonography Ultrasonography Aged Breast Neoplasms Metabolism Breast Neoplasms Pathology Carcinoma, Ductal, Breast Metabolism Carcinoma, Ductal, Breast Pathology Carcinoma, Lobular Metabolism Carcinoma, Lobular Pathology Female Human Middle Age Receptors, Cell Surface Metabolism Proteins Metabolism Retrospective Design Aged: 65+ years Middle Aged: 45-64 years Female ab: Background: The aim of this study was to evaluate the relation of some ultrasound morphological parameters to biological characteristics in breast carcinoma.Methods: Ultrasound data from 315 breast masses were collected. We analyzed the ultrasound features of the tumors according to the ACR BI-RADS®-US classification system stratified by hormone receptor status, HER2 status, histology grade, tumor type (ductal versus lobular), triple-negativity, breast density, tumor size, lymph node involvement and patient's age.Results: We found a variety of ultrasound features that varied between the groups. Invasive lobular tumors were more likely to have an angulated margin (39% versus 22%, p = 0.040) and less likely to show posterior acoustic enhancement (3% versus 16%, p = 0.023) compared to invasive ductal carcinoma. G3 tumors were linked to a higher chance of posterior acoustic enhancement and less shadowing and the margin of G3 tumors was more often described as lobulated or microlobulated compared to G1/G2 tumors (67% versus 46%, p = 0.001). Tumors with an over-expression of HER2 exhibited a higher rate of architectural distortions in the surrounding tissue, but there were no differences regarding the other features. Hormone receptor negative tumors were more likely to exhibit a lobulated or microlobulated margin (67% versus 50%, p = 0.037) and less likely to have an echogenic halo (39% versus 64%, p = 0.001). Furthermore, the posterior acoustic feature was more often described as enhancement (33% versus 13%, p = 0.001) and less often as shadowing (20% versus 47%, p < 0.001) compared to hormone receptor positive tumors.Conclusion: Depending on their biological and clinical profile, breast cancers are more or less likely to exhibit the typical criteria for malignancy in ultrasound. Moreover, certain types of breast cancer tend to possess criteria that are usually associated with benign masses. False-negative diagnosis may result in serious consequences for the patient. For the sonographer it is essential to be well aware of potential variations in the ultrasound morphology of breast tumors, as described in this paper. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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