Protective Effects of p38 MAPK Inhibitor SB202190 against Hippocampal Apoptosis and Spatial Learning and Memory Deficits in a Rat Model of Vascular Dementia.
Vascular dementia (VaD) is a common age-related neurodegenerative disease resulting from chronic hypoxia. In the present study, we examined the protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a chronic hypoperfusion rat mode...
| Publicado en: | BioMed Research International Vol. 2013; pp. 215798 - 215799 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104008849&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104008849 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 2013 vid: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104008849 104008849 2012451499 NLM24455679 PMC3886604 104008849 ppf: 215798 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Protective Effects of p38 MAPK Inhibitor SB202190 against Hippocampal Apoptosis and Spatial Learning and Memory Deficits in a Rat Model of Vascular Dementia. aug: au: Yang, Shen Zhou, Guangan Liu, Hong Zhang, Bo Li, Juan Cui, Ruiting Du, Yifeng affil: Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan 250012, China ; Department of Neurology, Taian Central Hospital, Taian 271000, China. sug: subj: Imidazoles Administration and Dosage Learning Disorders Drug Therapy Memory Disorders Drug Therapy Pyridines Administration and Dosage Transferases Metabolism Animal Studies Apoptosis Drug Effects Dementia, Vascular Drug Therapy Dementia, Vascular Physiopathology Genes Drug Effects Hippocampus Drug Effects Human Learning Disorders Physiopathology Memory Disorders Physiopathology Models, Biological Neurons Drug Effects Neurons Metabolism Proteins Rats Transferases Transferases Antagonists and Inhibitors ab: Vascular dementia (VaD) is a common age-related neurodegenerative disease resulting from chronic hypoxia. In the present study, we examined the protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a chronic hypoperfusion rat model of VaD established by permanent bilateral carotid occlusion (2-VO). Sixty rats were randomly divided into sham-operated, VaD model, and VaD plus SB202190 groups (n = 20/group). After sham/2-VO surgery, rats were administered 0.1% DMSO (sham-operated and VaD groups) or SB202190 by intracerebroventricular injection. One week after inhibitor/vehicle treatment, hippocampal p38 MAPK phosphorylation was higher in the model group than in the SB202190 group (P < 0.01). Compared to the model group, the SB202190 group exhibited significantly shorter escape latencies in the Morris water maze hidden platform trials (P < 0.01) and longer times in the original platform quadrant during probe trials (P < 0.01). The SB202190 group also showed significantly reduced neuronal apoptosis in the hippocampus compared to VaD model rats (P < 0.01) as well as higher (antiapoptotic) Bcl-2 expression and lower (proapoptotic) caspase-3 expression (P < 0.01 for both). In conclusion, blockade of the p38 MAPK signaling pathway by SB202190 following permanent 2-OV reduced apoptosis of hippocampal neurons and rescued spatial learning and memory deficits. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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