A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects.
Purpose: The aim of the study was to investigate how a diet high in dietary fiber, with several fiber sources included, modulates glucose and lipid metabolism and the inflammatory response in humans. Methods: Subjects ( n = 25) aged 58.6 (1.1) years (mean and SD) with a BMI of 26.6 (0.5) kg/m and a...
| Publicado en: | European Journal of Nutrition Vol. 53; no. 1; pp. 39 - 49 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Feb2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104014715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104014715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2014 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104014715 94176893 10.1007/s00394-013-0496-8 NLM23389112 104014715 ppf: 39 ppct: 10 formats: fmt: @attributes: type: P tig: atl: A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects. aug: au: Johansson-Persson, Anna Ulmius, Matilda Cloetens, Lieselotte Karhu, Toni Herzig, Karl-Heinz Önning, Gunilla affil: Biomedical Nutrition, Pure and Applied Biochemistry, Center for Applied Life Sciences, Lund University, SE-22100 Lund Sweden sug: subj: Dietary Fiber Administration and Dosage Glucose Metabolism Cholesterol Blood Inflammation Hypercholesterolemia Diet Therapy Human Randomized Controlled Trials Random Assignment Intervention Trials Pretest-Posttest Design Funding Source Dietary Fiber Pharmacodynamics Sweden Crossover Design Adult Middle Age Aged Body Mass Index Evaluation Male Female Single-Blind Studies Insulin Blood Blood Glucose Analysis Lipoproteins, HDL Cholesterol Blood Triglycerides Blood Lipoproteins, LDL Cholesterol Blood Nutritional Assessment Questionnaires Diet Records Cytokines Blood Interleukins Blood Interferons Blood Tumor Necrosis Factor Blood Descriptive Statistics Data Analysis Software Wilcoxon Signed Rank Test Two-Tailed Test Paired T-Tests Friedman Test Body Weights and Measures C-Reactive Protein Blood Fibrinogen Blood Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: The aim of the study was to investigate how a diet high in dietary fiber, with several fiber sources included, modulates glucose and lipid metabolism and the inflammatory response in humans. Methods: Subjects ( n = 25) aged 58.6 (1.1) years (mean and SD) with a BMI of 26.6 (0.5) kg/m and a total cholesterol (TC) of 5.8 (0.1) mmol/L (mean and SEM) were given a high fiber (HF) and low fiber (LF) diet, in a randomized controlled 5-week crossover intervention, separated by a 3-week washout. The HF diet consisted of oat bran, rye bran, and sugar beet fiber incorporated into test food products; one bread roll, one ready meal, and two beverages consumed daily. Equivalent food products, without added fibers, were provided in the LF diet. Results: Total dietary fiber intake was 48.0 g and 30.2 g per day for the HF and LF diet, respectively. Significant reduction in C-reactive protein (CRP) was observed between the diets ( P = 0.017) and a significant reduction in fibrinogen within the HF diet ( P = 0.044). There were no significant effects in other measured circulating cytokines or in glucose, insulin, and lipid levels. Conclusions: Our study suggests that a 5-week high dietary fiber intake of oat bran, rye bran, and sugar beet fiber might reduce the low-grade inflammatory response measured as CRP which could, together with reduced fibrinogen, help to prevent the risk of cardiovascular disease. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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