Contribution of creatine to protein homeostasis in athletes after endurance and sprint running.
Purpose: Few studies have focused on the metabolic changes induced by creatine supplementation. This study investigated the effects of creatine supplementation on plasma and urinary metabolite changes of athletes after endurance and sprint running. Methods: Twelve male athletes (20.3 ± 1.4 y) perfor...
| Publicado en: | European Journal of Nutrition Vol. 53; no. 1; pp. 61 - 72 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104014724&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104014724 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2014 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104014724 94176902 10.1007/s00394-013-0498-6 NLM23392621 104014724 ppf: 61 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Contribution of creatine to protein homeostasis in athletes after endurance and sprint running. aug: au: Tang, Fu-Chun Chan, Chun-Chen Kuo, Po-Ling affil: Graduate Institute of Nutritional Sciences and Education, #162, Hoping E. Rd. 1st Sec Taipei 10600 Taiwan, ROC sug: subj: Creatine Administration and Dosage Dietary Supplementation Running Muscle, Skeletal Metabolism Muscle Proteins Metabolism Carbohydrate Metabolism Human Taiwan Crossover Design Male Young Adult Descriptive Statistics Heart Rate Evaluation Exercise Test, Cardiopulmonary Exercise Intensity Body Composition Evaluation Blood Glucose Analysis Lactates Blood Amino Acids Blood Tryptophan Blood Glutamine Blood Alanine Blood Uric Acid Blood Urinalysis Blood Chemical Analysis Creatinine Urine Body Weights and Measures Statistical Significance Data Analysis Software One-Way Analysis of Variance Repeated Measures Paired T-Tests Post Hoc Analysis Athletes Athletic Performance Exercise Physiology Male ab: Purpose: Few studies have focused on the metabolic changes induced by creatine supplementation. This study investigated the effects of creatine supplementation on plasma and urinary metabolite changes of athletes after endurance and sprint running. Methods: Twelve male athletes (20.3 ± 1.4 y) performed two identical (65-70 % maximum heart rate reserved) 60 min running exercises (endurance trial) before and after creatine supplementation (12 g creatine monohydrate/day for 15 days), followed by a 5-day washout period. Subsequently, they performed two identical 100 m sprint running exercises (power trial) before and after 15 days of creatine supplementation in accordance with the supplementary protocol of the endurance trial. Body composition measurements were performed during the entire study. Plasma samples were examined for the concentrations of glucose, lactate, branched-chain amino acids (BCAAs), free-tryptophan (f-TRP), glutamine, alanine, hypoxanthine, and uric acid. Urinary samples were examined for the concentrations of hydroxyproline, 3-methylhistidine, urea nitrogen, and creatinine. Results: Creatine supplementation significantly increased body weights of the athletes of endurance trial. Plasma lactate concentration and ratio of f-TRP/BCAAs after recovery from endurance running were significantly decreased with creatine supplementation. Plasma purine metabolites (the sum of hypoxanthine and uric acid), glutamine, urinary 3-methylhistidine, and urea nitrogen concentrations tended to decrease before running in trials with creatine supplements. After running, urinary hydroxyproline concentration significantly increased in the power trial with creatine supplements. Conclusions: The findings suggest that creatine supplementation tended to decrease muscle glycogen and protein degradation, especially after endurance exercise. However, creatine supplementation might induce collagen proteolysis in athletes after sprint running. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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