A prospective, open-label, multicenter study of the clinical efficacy of extended-release hydromorphone in treating cancer pain inadequately controlled by other analgesics.
Purpose: The objective of this study was to evaluate whether extended-release hydromorphone (osmotic-controlled release oral delivery system [OROS] hydromorphone) treatment provided pain relief in cancer patients whose pain was inadequately controlled by other analgesics.Methods: In this prospective...
| Publicado en: | Supportive Care in Cancer Vol. 22; no. 3; pp. 741 - 751 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104018258&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104018258 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09414355 O1J jtl: Supportive Care in Cancer issn: 09414355 maglogo: N pubinfo: dt: Mar2014 vid: 22 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104018258 NLM24203087 2012466930 10.1007/s00520-013-2030-1 NLM24203087 104018258 ppf: 741 ppct: 10 formats: fmt: @attributes: type: P tig: atl: A prospective, open-label, multicenter study of the clinical efficacy of extended-release hydromorphone in treating cancer pain inadequately controlled by other analgesics. aug: au: Han, Hye-Suk Lee, Ki Hyeong Lee, Kyung Hee Ryu, Jeong Seon Kim, Young Chul Park, Seung Woo Oh, Ho-Suk Park, Kyung Tae Kwon, Jung Hye Lee, Pyung Bok Lee, Won Sik Kim, Yang Soo Ahn, Joong Bae Jeon, Seong Woo Lee, Sung Yong Seol, Young Mi Kang, Jung Hun Yuh, Young Jin Oh, So Yeon Kim, Suk Ran sug: subj: Analgesics, Opioid Therapeutic Use Breakthrough Pain Drug Therapy Delayed-Action Preparations Therapeutic Use Dihydromorphinone Therapeutic Use Neoplasms Complications Adult Aged Aged, 80 and Over Analgesics, Opioid Administration and Dosage Breakthrough Pain Etiology Delayed-Action Preparations Administration and Dosage Dihydromorphinone Administration and Dosage Drug Administration Schedule Female Human Male Middle Age Neoplasms Epidemiology Pain Measurement Prospective Studies Sleep Treatment Outcomes Young Adult Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: The objective of this study was to evaluate whether extended-release hydromorphone (osmotic-controlled release oral delivery system [OROS] hydromorphone) treatment provided pain relief in cancer patients whose pain was inadequately controlled by other analgesics.Methods: In this prospective, open-label, multicenter trial, patients who have sustained cancer pain with other analgesics were enrolled. After the baseline evaluation (visit 1), OROS hydromorphone was administered. Two evaluations (visits 2 and 3) were made: 29 ± 7 and 57 ± 7 days later, respectively. The primary end point was the pain intensity difference (PID) at visit 3 relative to visit 1 (expressed as percent PID).Results: In total, 879 patients were screened and 432 completed all three visits. Of the 874 full analysis set patients, 343 (39.2 %) improved by more than 30 % PID. Of the 432 per-protocol patients, 282 (65.3 %) improved by more than 30 % PID. At visits 2 and 3, the degree of sleep disturbance, the number of awakenings, and the degree of sleep satisfaction were significantly better than at visit 1 (all P < 0.0001 for both visit 1-visit 2 and visit 1-visit 3). However, this pain relief was not associated with improved quality of life (P = 0.326 and P = 0.055 for visit 1-visit 2 and visit 1-visit 3, respectively).Conclusions: This study suggested that active pain management using the strong opioid OROS hydromorphone was beneficial in the management of cancer pain that was not controlled by other analgesics. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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