Meaningful improvement in walking performance after Botulinum Neurotoxin A (BoNT-A) in chronic spastic patients.
BACKGROUND: Botulinum neurotoxin A (BoNT-A) may reduce lower limb spasticity but its role in improving walking ability remains to be established. OBJECTIVE: To investigate the efficacy of simultaneous BoNT-A injections into several targeted spastic muscles of different joints on gait speed and on fu...
| Publicado en: | NeuroRehabilitation Vol. 34; no. 1; pp. 185 - 193 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104019546&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104019546 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: 2014 vid: 34 iid: 1 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 104019546 94316555 10.3233/NRE-131021 NLM24284465 104019546 ppf: 185 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Meaningful improvement in walking performance after Botulinum Neurotoxin A (BoNT-A) in chronic spastic patients. aug: au: Cioncoloni, David Taddei, Sabrina Bielli, Silvia Annunziata, Pasquale Mazzocchio, Riccardo affil: U.O.P. Professioni della Riabilitazione, Azienda Ospedaliera Universitaria Senese, Siena, Italy sug: subj: Spasm Drug Therapy Chronic Disease Botulinum Toxins Therapeutic Use Walking Treatment Outcomes Human Stroke Complications Multiple Sclerosis Complications Clinical Assessment Tools Scales Outpatients Prospective Studies Italy T-Tests Mann-Whitney U Test Repeated Measures Analysis of Variance Friedman Test Post Hoc Analysis Linear Regression Data Analysis Software Male Female Adult Middle Age Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: BACKGROUND: Botulinum neurotoxin A (BoNT-A) may reduce lower limb spasticity but its role in improving walking ability remains to be established. OBJECTIVE: To investigate the efficacy of simultaneous BoNT-A injections into several targeted spastic muscles of different joints on gait speed and on functional gains in gait performance in chronic stroke and MS patients. METHODS: Twenty patients affected by stroke or multiple sclerosis were tested before, one and three months after BoNT-A administration. Gait was evaluated by the 10 Meter Walk Test; patients were stratified into functional ambulation classes accordingly. Spasticity was assessed using the modified Ashworth Scale. RESULTS: At final assessment, spasticity was reduced in hip adductors and ankle plantar-flexors, gait speed improved and, 1/3rd of patients transitioned to a higher ambulation class. The pre-post difference in Level of Spasticity of the hips was a predictor for an increase in gait speed. CONCLUSIONS: A meaningful improvement in walking performance can be obtained in chronic spastic patients after BoNT-A injection into several muscles, specifically the hip adductors. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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