Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation.
After allogeneic hematopoietic cell transplantation (alloHCT) liver biopsy is performed for enigmatic liver disorders when noninvasive diagnostic steps have failed in establishing a definitive diagnosis. This document provides an updated consensus on the prerequisites for proper evaluation of liver...
| Published in: | Virchows Archiv: European Journal of Pathology Vol. 464; no. 2; pp. 175 - 191 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Feb2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104022247&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104022247 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Feb2014 vid: 464 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104022247 NLM24385287 2012474165 10.1007/s00428-013-1528-8 NLM24385287 104022247 ppf: 175 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation. aug: au: Stift, Judith Baba, Hideo A Huber, Elisabeth Federmann, Birgit Fischer, Hans-Peter Schmitt-Graeff, Annette Baurmann, Herrad Bethge, Wolfgang Schirmacher, Peter Wrba, Fritz Greinix, Hildegard Fend, Falko Schwerdtfeger, Rainer Shulman, Howard M Wolff, Daniel Longerich, Thomas affil: Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria. sug: subj: Graft Versus Host Disease Diagnosis Hematopoietic Stem Cell Transplantation Adverse Effects Liver Pathology Adolescence Adult Aged Biopsy Child Child, Preschool Female Male Middle Age Allografts Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Child: 6-12 years Child, Preschool: 2-5 years Middle Aged: 45-64 years Female Male ab: After allogeneic hematopoietic cell transplantation (alloHCT) liver biopsy is performed for enigmatic liver disorders when noninvasive diagnostic steps have failed in establishing a definitive diagnosis. This document provides an updated consensus on the prerequisites for proper evaluation of liver biopsies in alloHCT patients and the histological diagnostic criteria for liver graft-versus-host disease (GvHD). The Working Group's recommendations for the histological diagnosis of liver GvHD were derived from the peer-reviewed literature and from the consensus diagnosis of a total of 30 coded liver biopsies. Acceptance of the recommendations was tested by a survey distributed to all HCT centers in Austria, Germany and Switzerland. Consensus was achieved for biopsy indications, methods of sample acquisition and processing, reporting and interpretation of biopsy findings. As GvHD is variably treated and the treatment modalities have changed over time, the panel endorses the use of more frequent biopsies in clinical studies in order to improve the present challenging clinical and diagnostic situation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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