Can dogs smell lung cancer? First study using exhaled breath and urine screening in unselected patients with suspected lung cancer.
Background. On the basis of our own experience and literature search, we hypothesised that a canine olfactory test may be useful for detecting lung cancer in an unselected population of patients suspected to have lung cancer. Material and methods. We conducted a prospective study of 93 patients cons...
| Publicado en: | Acta Oncologica Vol. 53; no. 3; pp. 307 - 316 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Medical Journals Sweden AB
Mar2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104023285&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104023285 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0284186X B84 jtl: Acta Oncologica issn: 0284186X maglogo: N pubinfo: dt: Mar2014 vid: 53 iid: 3 pid: 59195 pub: Medical Journals Sweden AB artinfo: ui: 104023285 94379319 10.3109/0284186X.2013.819996 NLM23957595 104023285 ppf: 307 ppct: 9 formats: tig: atl: Can dogs smell lung cancer? First study using exhaled breath and urine screening in unselected patients with suspected lung cancer. aug: au: Amundsen, Tore Sundstrøm, Stein Buvik, Turid Gederaas, Odrun Arna Haaverstad, Rune affil: Department of Thoracic Medicine, St. Olavs Hospital HF, Trondheim, Norway; Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway sug: subj: Lung Neoplasms Diagnosis Dogs Smell Breath Tests Lung Neoplasms Urine Prospective Studies Animal Studies Human Sensitivity and Specificity Videorecording Data Analysis Software Bivariate Statistics Male Female Adult Middle Age Aged Aged, 80 and Over Descriptive Statistics Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background. On the basis of our own experience and literature search, we hypothesised that a canine olfactory test may be useful for detecting lung cancer in an unselected population of patients suspected to have lung cancer. Material and methods. We conducted a prospective study of 93 patients consecutively admitted to hospital with suspected lung cancer. Exhaled breath and urine were sampled before the patients underwent bronchoscopy. The canine olfactory test was performed in a double-blinded manner. Sensitivity and specificity were outcome measures. Results. With 99% sensitivity, the olfactory test demonstrated that dogs have the ability to distinguish cancer patients from healthy individuals. With an intensified training procedure, the exhaled breath and urine tests showed sensitivity rates of 56-76% and specificity rates of 8.3-33.3%, respectively, in our heterogeneous study population. Conclusion. Although the olfactory test appears to be a promising tool for the detection of cancer, the main challenge is to determine whether the test can sufficiently discriminate between patients at risk, patients with benign disease, and patients with malignant disease. We need to gain a deeper understanding of this test and further refine it before applying it as a screening tool for lung cancer in clinical settings. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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