hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment.

Drug Mode of Action and hERG-Related Safety Introduction Since the discovery of the link that exists between drug-induced hERG inhibition and Torsade de Pointes (TdP), extreme attention has been given to avoid new drugs inhibiting this channel. hERG inhibition is routinely screened for in new drugs...

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Publicado en:	Journal of Cardiovascular Electrophysiology Vol. 25; no. 2; pp. 197 - 208
Autores principales:	Veroli, Giovanni Y., Davies, Mark R., Zhang, Henggui, Abi-Gerges, Najah, Boyett, Mark R.
Formato:	equations & formulas research tables/charts Journal Article
Publicado:	Wiley-Blackwell Feb2014
Acceso en línea:	Ver este registro en EBSCOhost