Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial.
The last two decades have witnessed a surge in research investigating the application of oxytocin as a method of enhancing social behaviour in humans. Preliminary evidence suggests oxytocin may have potential as an intervention for autism. We evaluated a 5-day 'live-in' intervention using a double-b...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 44; no. 3; pp. 521 - 532 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104024520&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104024520 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Mar2014 vid: 44 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104024520 94344402 10.1007/s10803-013-1899-3 NLM23888359 104024520 ppf: 521 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial. aug: au: Dadds, Mark MacDonald, Elayne Cauchi, Avril Williams, Katrina Levy, Florence Brennan, John affil: School of Psychology, University of New South Wales, Sydney 2052 Australia sug: subj: Oxytocin Therapeutic Use Administration, Intranasal In Infancy and Childhood Autism Spectrum Disorder Drug Therapy Social Behavior Drug Effects Drug Therapy Evaluation Human Funding Source Randomized Controlled Trials Child Male Adolescence New South Wales Asperger Syndrome Pervasive Developmental Disorder-Not Otherwise Specified Comorbidity Scales Interview Guides Interviews Reliability and Validity Multidisciplinary Care Team Prospective Studies Family Relations Education Drug Administration Schedule Oxytocin Administration and Dosage Teaching Materials Clinical Assessment Tools Videorecording Pretest-Posttest Design Interrater Reliability Confidence Intervals Odds Ratio Summated Rating Scaling Data Analysis Software One-Way Analysis of Variance Descriptive Statistics Communication Skills Evaluation Repeated Measures Child: 6-12 years Adolescent: 13-18 years Male ab: The last two decades have witnessed a surge in research investigating the application of oxytocin as a method of enhancing social behaviour in humans. Preliminary evidence suggests oxytocin may have potential as an intervention for autism. We evaluated a 5-day 'live-in' intervention using a double-blind randomized control trial. 38 male youths (7-16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days. The oxytocin or placebo was administered during parent-child interaction training sessions. Parent and child behaviours were assessed using parent reports, clinician ratings, and independent observations, at multiple time points to measure side-effects; social interaction skills; repetitive behaviours; emotion recognition and diagnostic status. Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders. The results show that the benefits of nasal oxytocin for young individuals with autism spectrum disorders may be more circumscribed than suggested by previous studies, and suggest caution in recommending it as an intervention that is broadly effective. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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