Prolonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder.
This fMRI study examined whether hemodynamic responses to affectively-salient stimuli were abnormally prolonged in remitted bipolar disorder, possibly representing a novel illness biomarker. A group of 18 DSM-IV bipolar I-diagnosed adults in remission and a demographically-matched control group perf...
| Publicado en: | Brain Imaging & Behavior Vol. 8; no. 1; pp. 73 - 87 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104026858&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104026858 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Mar2014 vid: 8 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104026858 NLM23975275 2012481143 10.1007/s11682-013-9246-z NLM23975275 PMC3944373 104026858 ppf: 73 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Prolonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder. aug: au: Rosenfeld, Ethan S Pearlson, Godfrey D Sweeney, John A Tamminga, Carol A Keshavan, Matcheri S Nonterah, Camilla Stevens, Michael C affil: Olin Neuropsychiatry Research Center, The Institute of Living/Hartford Hospital, 200 Retreat Ave, Whitehall Building, Hartford, CT, 06106, USA. sug: subj: Bipolar Disorder Physiopathology Cerebrovascular Circulation Emotions Facial Expression Oxygen Metabolism Adult Analysis of Variance Bipolar Disorder Psychosocial Factors Brain Mapping Face Female Human Magnetic Resonance Imaging Male Neuropsychological Tests Physical Stimulation Time Factors Visual Perception Adult: 19-44 years Female Male ab: This fMRI study examined whether hemodynamic responses to affectively-salient stimuli were abnormally prolonged in remitted bipolar disorder, possibly representing a novel illness biomarker. A group of 18 DSM-IV bipolar I-diagnosed adults in remission and a demographically-matched control group performed an event-related fMRI gender-discrimination task in which face stimuli had task-irrelevant neutral, happy or angry expressions designed to elicit incidental emotional processing. Participants' brain activation was modeled using a "fully informed" SPM5 basis set. Mixed-model ANOVA tested for diagnostic group differences in BOLD response amplitude and shape within brain regions-of-interest selected from ALE meta-analysis of previous comparable fMRI studies. Bipolar-diagnosed patients had a generally longer duration and/or later-peaking hemodynamic response in amygdala and numerous prefrontal cortex brain regions. Data are consistent with existing models of bipolar limbic hyperactivity, but the prolonged frontolimbic response more precisely details abnormalities recognized in previous studies. Prolonged hemodynamic responses were unrelated to stimulus type, task performance, or degree of residual mood symptoms, suggesting an important novel trait vulnerability brain dysfunction in bipolar disorder. Bipolar patients also failed to engage pregenual cingulate and left orbitofrontal cortex-regions important to models of automatic emotion regulation-while engaging a delayed dorsolateral prefrontal cortex response not seen in controls. These results raise questions about whether there are meaningful relationships between bipolar dysfunction of specific ventromedial prefrontal cortex regions believed to automatically regulate emotional reactions and the prolonged responses in more lateral aspects of prefrontal cortex. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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