Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans.
Purpose: Our objective was to compare the absorption of microencapsulated ferric saccharate (MFS) and ferrous sulfate (FS) in a fortified milk product, using a crossover design. Methods: Seventeen non-iron-deficient healthy adults from both sexes participated in the study. On each intervention day (...
| Publicado en: | European Journal of Nutrition Vol. 53; no. 2; pp. 567 - 575 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104030191&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104030191 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2014 vid: 53 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104030191 94448851 10.1007/s00394-013-0565-z NLM23892521 104030191 ppf: 567 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Comparative study of the oral absorption of microencapsulated ferric saccharate and ferrous sulfate in humans. aug: au: Contreras, Carlos Barnuevo, María Guillén, Isabel Luque, Antonio Lázaro, Elisabet Espadaler, Jordi López-Román, Javier Villegas, José affil: Cátedra de Fisiología del Ejercicio, Departamento de Ciencias de la Salud, Universidad Católica San Antonio, Campus de los Jerónimos s/n 30107 Guadalupe, Murcia Spain sug: subj: Ferrous Compounds Pharmacokinetics Milk Food, Fortified Intestinal Absorption Biological Availability Ferrous Compounds Administration and Dosage Human Randomized Controlled Trials Random Assignment Double-Blind Studies Spain Crossover Design Male Female Iron Blood Postprandial Period Transferrin Blood Adolescence Young Adult Adult Descriptive Statistics Body Mass Index Evaluation Two-Way Analysis of Variance Repeated Measures Data Analysis Software Drug Compounding Methods Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Purpose: Our objective was to compare the absorption of microencapsulated ferric saccharate (MFS) and ferrous sulfate (FS) in a fortified milk product, using a crossover design. Methods: Seventeen non-iron-deficient healthy adults from both sexes participated in the study. On each intervention day (days 1 and 8), after an overnight fast, the volunteers consumed one type of product (test or control) and blood sampling was carried out at different times. The interventions days were separated by 7-day washout periods. This study was double blinded, crossover and randomized for nature of the test meals. The primary outcomes of the study were total serum iron and transferrin saturation. Results: No significant differences could be observed in serum iron concentration during the 6-h postprandial study due to the type of milk product consumed, and there was neither an effect of time nor an interaction between the type of milk product and time. Transferrin saturation significantly increased after the intake of both products ( P < 0.005), reaching a peak value between hours 2 and 4. No significant differences were detected between MFS and FS, indicating that iron absorption from MFS is equivalent to absorption from FS. Conclusions: MFS is a new ingredient that allows the fortification of a wide range of food products, including heat-processed and non-acidic products with similar absorption to FS, designed to produce neither organoleptic changes nor off-color development during storage of fortified food. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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