Cover Image
QR Code

Atypical Antipsychotic-Induced Metabolic Disturbances in the Elderly.

The metabolic side effects of atypical antipsychotics (AAPs) have been widely studied in younger populations, but research investigating these sequelae in the elderly is lacking. This article reviews the available literature examining the use of AAPs in the elderly, evaluating their association with...

Full description

Published in:Drugs & Aging Vol. 31; no. 3; pp. 159 - 185
Main Authors: Guenette, Melanie, Chintoh, Araba, Remington, Gary, Hahn, Margaret
Format: research systematic review tables/charts Journal Article
Published: Springer Nature Mar2014
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104034213&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 104034213
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        1170229X
        C5B
      jtl: Drugs & Aging
      issn: 1170229X
      maglogo: N
    pubinfo:
      dt: Mar2014
      vid: 31
      iid: 3
      pid: 237
      pub: Springer Nature
      place: New York, New York
    artinfo:
      ui:
        104034213
        94694334
        10.1007/s40266-014-0152-x
        NLM24477569
        104034213
      ppf: 159
      ppct: 26
      formats:
        fmt:
          @attributes:
            type: P
      tig:
        atl: Atypical Antipsychotic-Induced Metabolic Disturbances in the Elderly.
      aug:
        au:
          Guenette, Melanie
          Chintoh, Araba
          Remington, Gary
          Hahn, Margaret
        affil: Centre for Addiction and Mental Health, 250 College Street Toronto M5T 1R8 Canada
      sug:
        subj:
          Metabolic Diseases Chemically Induced
          Antipsychotic Agents Adverse Effects
          Metabolic Diseases Etiology
          Human
          Antipsychotic Agents Classification
          Systematic Review
          PubMed
          Olanzapine Pharmacodynamics
          Quetiapine Pharmacodynamics
          Risperidone Pharmacodynamics
          Blood Glucose Drug Effects
          Aged
          Aged: 65+ years
      ab: The metabolic side effects of atypical antipsychotics (AAPs) have been widely studied in younger populations, but research investigating these sequelae in the elderly is lacking. This article reviews the available literature examining the use of AAPs in the elderly, evaluating their association with weight gain and changes in blood glucose and lipid parameters. We find a relative paucity of studies in this area; while some data highlight significant, collective changes in metabolic parameters, the majority suggests an apparent low vulnerability to these side effects. We conclude that the risk and clinical implications of unfavorable metabolic changes in the elderly being treated with AAP medications remain largely undetermined, and we caution against drawing firm conclusions based on the available data. The conflicting evidence leaves us recommending that metabolic monitoring be implemented, with regular follow-up as advocated in other populations.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N