Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla.
Objectives: To investigate whether a new magnetic resonance image (MRI) technique called T2*-weighted fluid attenuation inversion recovery (FLAIR*) can differentiate between multiple sclerosis (MS) and vascular brain lesions, at 7 Tesla (T).Methods: We examined 16 MS patients and 16 age-matched pati...
| Publicado en: | European Radiology Vol. 24; no. 4; pp. 841 - 850 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104037789&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104037789 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2014 vid: 24 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104037789 NLM24317461 2012499154 10.1007/s00330-013-3080-y NLM24317461 104037789 ppf: 841 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla. aug: au: Kilsdonk, Iris D Wattjes, Mike P Lopez-Soriano, Alexandra Kuijer, Joost P A de Jong, Marcus C de Graaf, Wolter L Conijn, Mandy M A Polman, Chris H Luijten, Peter R Geurts, Jeroen J G Geerlings, Mirjam I Barkhof, Frederik affil: Department of Radiology, VU University Medical Center, De Boelelaan 1118, 1081, HZ, Amsterdam, The Netherlands, i.kilsdonk@vumc.nl. sug: subj: Brain Pathology Image Processing, Computer Assisted Magnetic Resonance Imaging Methods Multiple Sclerosis Pathology Adult Brain Blood Supply Case Control Studies Diagnosis, Differential Female Human Male Middle Age Sensitivity and Specificity Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: To investigate whether a new magnetic resonance image (MRI) technique called T2*-weighted fluid attenuation inversion recovery (FLAIR*) can differentiate between multiple sclerosis (MS) and vascular brain lesions, at 7 Tesla (T).Methods: We examined 16 MS patients and 16 age-matched patients with (risk factors for) vascular disease. 3D-FLAIR and T2*-weighted images were combined into FLAIR* images. Lesion type and intensity, perivascular orientation and presence of a hypointense rim were analysed.Results: In total, 433 cerebral lesions were detected in MS patients versus 86 lesions in vascular patients. Lesions in MS patients were significantly more often orientated in a perivascular manner: 74 % vs. 47 % (P < 0.001). Ten MS lesions (2.3 %) were surrounded by a hypointense rim on FLAIR*, and 24 MS lesions (5.5 %) were hypointense on T2*. No lesions in vascular patients showed any rim or hypointensity. Specificity of differentiating MS from vascular lesions on 7-T FLAIR* increased when the presence of a central vessel was taken into account (from 63 % to 88 %), most obviously for deep white matter lesions (from 69 % to 94 %). High sensitivity remained (81 %).Conclusion: 7-T FLAIR* improves differentiation between MS and vascular lesions based on lesion location, perivascular orientation and presence of hypointense (rims around) lesions.Key Points: • A new MRI technique T2*-weighted fluid attenuation inversion recovery (FLAIR*) was investigated. • FLAIR* at 7-T MRI combines FLAIR and T2* images into a single image. • FLAIR* at 7 T does not require enhancement with contrast agents. •High-resolution 7-T FLAIR* improves differentiation between MS and vascular brain lesions. • FLAIR* revealed a central vessel more frequently in MS than vascular lesions. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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