Allopurinol enhanced thiopurine treatment for inflammatory bowel disease: safety considerations and guidelines for use.
What is known and objective The thiopurine medications are standard inflammatory bowel disease treatments. Therapeutic failure is observed, however, often because of variable drug metabolism. Allopurinol can enhance the potency of thiopurine treatment. Our objective is to review the relevant literat...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 39; no. 2; pp. 107 - 112 |
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| Autores principales: | , , |
| Formato: | tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104039004&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104039004 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Apr2014 vid: 39 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104039004 94743520 10.1111/jcpt.12125 NLM24438369 104039004 ppf: 107 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Allopurinol enhanced thiopurine treatment for inflammatory bowel disease: safety considerations and guidelines for use. aug: au: Min, M. X. Weinberg, D. I. McCabe, R. P. affil: Abbott Northwestern Hospital sug: subj: Inflammatory Bowel Diseases Drug Therapy Allopurinol Therapeutic Use Immunosuppressive Agents Therapeutic Use Treatment Outcomes Drug Therapy, Combination Evaluation ab: What is known and objective The thiopurine medications are standard inflammatory bowel disease treatments. Therapeutic failure is observed, however, often because of variable drug metabolism. Allopurinol can enhance the potency of thiopurine treatment. Our objective is to review the relevant literature, and our own experience, to determine if allopurinol enhancement of thiopurine treatment is a reasonable therapeutic strategy. Comment Published reports of, and our own experience using, allopurinol-thiopurine combination therapy indicate that the addition of allopurinol will enhance thiopurine treatment in up to 60% of patients. There are risks to this approach, but with appropriate monitoring, these risks should approximate those observed with thiopurine therapy alone. What is new and conclusion Combination therapy with allopurinol and a thiopurine is a reasonable alternative for inflammatory bowel disease patients not responding to thiopurine monotherapy. Physicians experienced in thiopurine treatment, who have familiarity with thiopurine metabolism, and are willing to engage in appropriate therapeutic monitoring, should consider this strategy. pubtype: Academic Journal doctype: tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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