Duration of opiate exposure as a determinant of arterial stiffness and vascular age in male opiate dependence: a longitudinal study.
What is known and objective Despite intriguing initial and associational studies, there remains little research on opiate-related arterial dysfunction and no longitudinal studies. As opiates act potently via P16 INK4 A/ CDKN2 A identified on GWAS screens, and as arterial ageing is a surrogate for or...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 39; no. 2; pp. 158 - 168 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104039006&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104039006 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Apr2014 vid: 39 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104039006 94743521 10.1111/jcpt.12121 NLM24329809 104039006 ppf: 158 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Duration of opiate exposure as a determinant of arterial stiffness and vascular age in male opiate dependence: a longitudinal study. aug: au: Reece, A. S. Hulse, G. K. affil: School of Psychiatry and Clinical Neurosciences, University of Western Australia sug: subj: Narcotics Adverse Effects Arteries Physiopathology Cardiovascular System Drug Effects Prospective Studies Human Male Data Analysis Software Adult Descriptive Statistics Parametric Statistics Chi Square Test T-Tests Repeated Measures Multiple Regression Linear Regression Adult: 19-44 years Male ab: What is known and objective Despite intriguing initial and associational studies, there remains little research on opiate-related arterial dysfunction and no longitudinal studies. As opiates act potently via P16 INK4 A/ CDKN2 A identified on GWAS screens, and as arterial ageing is a surrogate for organismal ageing, this area is of general concern. Methods Thirty-eight male controls compared with 198 opiate-dependent male patients were studied longitudinally using Sphygmo Cor pulse wave analysis. Results and discussion Healthy male controls and opiate-dependent male patients were studied on 125 and 625 occasions, respectively. The mean (±SEM) chronological age ( CA) was 42·32 ± 2·22 for controls and 35·04 ± 0·61 for opiate dependent ( P = 0·0029). 94·4% and 13·2% smoked tobacco ( P < 0·0001). Controlling for BMI and CA, there was a significant time: addictive status interaction for vascular age ( P = 0·0127) and central augmentation pressure and index (both P < 0·02). Central systolic and diastolic pressures were also worse over time by addictive status ( P < 0·005). At repeated measures multiple regression adjusted for classical risk factors, opiate dose and duration of opiate use remained significant. The dose-duration effect was significant in 8 terms and by time. A similar model quadratic in opiate duration was more powerfully predictive, suggesting the salience of the duration of opiate treatment ( AIC 191·6898 and 191·5966, P = 0·0116). What is new and conclusion Data suggest that increased length of opiate dependence is associated with advanced vascular stiffness and ageing and are therefore consistent with accelerated ageing organismally. The superiority of power functions of the opiate duration of exposure underscores the significance of the duration of treatment and of putative senescence induction. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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