Widespread alterations in functional brain network architecture in amnestic mild cognitive impairment.
We investigated changes in functional network architecture in amnestic mild cognitive impairment using graph-based analysis of task-free functional magnetic resonance imaging and fine cortical parcellation. Widespread disconnection was observed primarily in cortical hubs known to manifest early Alzh...
| Publicado en: | Journal of Alzheimer's Disease Vol. 38; no. 1; pp. 213 - 221 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Sage Publications Inc.
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104042980&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104042980 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13872877 FLR jtl: Journal of Alzheimer's Disease issn: 13872877 maglogo: N pubinfo: dt: 2014 vid: 38 iid: 1 pid: 20732 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 104042980 104042980 NLM24366921 2012504960 10.3233/JAD-131766 NLM24366921 104042980 ppf: 213 ppct: 8 formats: tig: atl: Widespread alterations in functional brain network architecture in amnestic mild cognitive impairment. aug: au: Minati, Ludovico Chan, Dennis Mastropasqua, Chiara Serra, Laura Spanò, Barbara Marra, Camillo Caltagirone, Carlo Cercignani, Mara Bozzali, Marco affil: Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Falmer, UK Scientific Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy. sug: subj: Brain Blood Supply Brain Pathology Cognition Disorders Neural Pathways Blood Supply Neural Pathways Pathology Aged Aged, 80 and Over Amnesia Complications Brain Mapping Female Human Image Processing, Computer Assisted Magnetic Resonance Imaging Male Psychological Tests Middle Age Cognition Disorders Complications Oxygen Blood Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: We investigated changes in functional network architecture in amnestic mild cognitive impairment using graph-based analysis of task-free functional magnetic resonance imaging and fine cortical parcellation. Widespread disconnection was observed primarily in cortical hubs known to manifest early Alzheimer's disease pathology, namely precuneus, parietal lobules, supramarginal and angular gyri, and cuneus, with additional involvement of subcortical regions, sensorimotor cortex and insula. The connectivity changes determined using graph-based analysis significantly exceed those detected using independent component analysis both in amplitude and topographical extent, and are largely decoupled from the presence of overt atrophy. This superior ability of graph-based analysis to detect disease-related disconnection highlights its potential use in the determination of biomarkers of early dementia. Graph-based analysis source code is provided as supplementary material. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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