Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model.
For assessing mechanical properties of osteoporotic bone, biomechanical testing combined with in silico modeling plays a key role. The present study focuses on microscopic mechanical bone properties in a rat model of postmenopausal osteoporosis. Female Sprague-Dawley rats were (1) euthanized without...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 52; no. 4; pp. 405 - 415 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104048255&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104048255 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Apr2014 vid: 52 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104048255 NLM24518991 2012516397 10.1007/s11517-014-1140-3 NLM24518991 104048255 ppf: 405 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. aug: au: Müller, Robert Kampschulte, Marian Khassawna, Thaqif El Schlewitz, Gudrun Hürter, Britta Böcker, Wolfgang Bobeth, Manfred Langheinrich, Alexander C Heiss, Christian Deutsch, Andreas Cuniberti, Gianaurelio affil: Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology, 01062, Dresden, Germany, robert.mueller@tu-dresden.de. sug: subj: Kinematics Physiology Osteoporosis Physiopathology Spine Physiopathology Animal Studies Compressive Strength Elasticity Female Finite Element Analysis Oophorectomy Osteoporosis Radiography Rats Spine Radiography Female ab: For assessing mechanical properties of osteoporotic bone, biomechanical testing combined with in silico modeling plays a key role. The present study focuses on microscopic mechanical bone properties in a rat model of postmenopausal osteoporosis. Female Sprague-Dawley rats were (1) euthanized without prior interventions, (2) sham-operated, and (3) subjected to ovariectomy combined with a multi-deficiencies diet. Rat vertebrae (corpora vertebrae) were imaged by micro-CT, their stiffness was determined by compression tests, and load-induced stress states as well as property changes due to the treatment were analyzed by finite-element modeling. By comparing vertebra stiffness measurements with finite-element calculations of stiffness, an overall microscopic Young's modulus of the bone was determined. Macroscopic vertebra stiffness as well as the microscopic modulus diminish with progression of osteoporosis by about 70 %. After strong initial changes of bone morphology, further decrease in macroscopic stiffness is largely due to decreasing microscopic Young's modulus. The micromechanical stress calculations reveal particularly loaded vertebra regions prone to failure. Osteoporosis-induced changes of the microscopic Young's modulus alter the fracture behavior of bone, may influence bone remodeling, and should be considered in the design of implant materials. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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