The effects of pH on wound healing, biofilms, and antimicrobial efficacy.
It is known that pH has a role to play in wound healing. In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses i...
| Publicado en: | Wound Repair & Regeneration Vol. 22; no. 2; pp. 174 - 187 |
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| Autores principales: | , , , |
| Formato: | review Journal Article |
| Publicado: |
Wiley-Blackwell
Mar/Apr2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104048675&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104048675 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Mar/Apr2014 vid: 22 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104048675 94956195 10.1111/wrr.12125 NLM24611980 104048675 ppf: 174 ppct: 13 formats: fmt: @attributes: type: P tig: atl: The effects of pH on wound healing, biofilms, and antimicrobial efficacy. aug: au: Percival, Steven L. McCarty, Sara Hunt, John A. Woods, Emma J. affil: Research & Development, Scapa Healthcare; Surface Science Research Centre, University of Liverpool; Clinical Engineering, United Kingdom Centre for Tissue Engineering, Institute of Ageing and Chronic Disease, University of Liverpool sug: subj: Hydrogen-Ion Concentration Wound Healing Biofilms Bacterial Infections Prevention and Control Enzymes Metabolism Fibroblasts Physiology Immune System Physiology Leukocytes Physiology Antibodies Lymphocytes Antibiotics ab: It is known that pH has a role to play in wound healing. In particular, pH has been shown to affect matrix metalloproteinase activity, tissue inhibitors of matrix metalloproteinases activity, fibroblast activity, keratinocyte proliferation, microbial proliferation, and also immunological responses in a wound; the patient's defense mechanisms change the local pH of a wound to effect microorganism invasion and proliferation; this pH change has been found to affect the performance of antimicrobials, and therefore the efficacy in biological environments directly relevant to wound healing. Based on the available body of scientific evidence to date, it is clear that pH has a role to play in both the healing of and treatment of chronic and acute wounds. It is the purpose of this review to evaluate the published knowledge base that concerns the effect of pH changes, the role it plays in wound healing and biofilm formation, and how it can affect treatment efficacy and wound management strategies. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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