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Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells.

Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), a natural polyphenolic compound, is known as a promising anti-cancer agent. In this study, we showed that RSV could inhibit the growth of B16 cells via induction of apoptosis. Moreover, our results showed for the first time that RSV induced autoph...

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Published in:Nutrition & Cancer Vol. 66; no. 3; pp. 435 - 441
Main Authors: Wang, Meng, Yu, Teng, Zhu, Chengyao, Sun, Hui, Qiu, Ying, Zhu, Xia, Li, Jinchao
Format: pictorial research tables/charts Journal Article
Published: Taylor & Francis Ltd Apr2014
Online Access:View this record in EBSCOhost
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        01635581
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      jtl: Nutrition & Cancer
      issn: 01635581
      maglogo: N
    pubinfo:
      dt: Apr2014
      vid: 66
      iid: 3
      pid: 377
      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        104054964
        95211331
        10.1080/01635581.2013.878738
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      tig:
        atl: Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells.
      aug:
        au:
          Wang, Meng
          Yu, Teng
          Zhu, Chengyao
          Sun, Hui
          Qiu, Ying
          Zhu, Xia
          Li, Jinchao
        affil: Department of Oncology, Shandong Jining No.1 People's Hospital, Jining, China
      sug:
        subj:
          Resveratrol Metabolism
          Cell Death Drug Effects
          Melanoma Drug Therapy
          Resveratrol Therapeutic Use
          Ceramidases
          Animal Studies
          Funding Source
          Tissue Culture Techniques
          Antibodies
          Mice
          Rabbits
          Blotting, Western
          Enzyme-Linked Immunosorbent Assay
          Fluorescent Antibody Technique
          Descriptive Statistics
          T-Tests
          Gene Expression
          Grape
          Research, Dietetics
      ab: Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), a natural polyphenolic compound, is known as a promising anti-cancer agent. In this study, we showed that RSV could inhibit the growth of B16 cells via induction of apoptosis. Moreover, our results showed for the first time that RSV induced autophagy in B16 cells, which might occur through ceramide accumulation and Akt/mTOR pathway inhibition. Inhibition of autophagy by an autophagic inhibitor 3-methyladenine (3-MA) or si-Beclin 1 enhanced RSV-induced cytotoxicity and apoptosis. Thus, autophagy inhibition represents a promising approach to improve the efficacy of RSV in the treatment of patients with melanoma.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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