Gene Expression Profile Analysis of T1 and T2 Breast Cancer Reveals Different Activation Pathways.
Breast cancers today are of predominantly T1 (0.1 ≥ 2.0 cm) or T2 (> 2 ≤ 5cm) categories due to early diagnosis. Molecular profiling using microarrays has led to the notion of breast cancer as a heterogeneous disease both clinically and molecularly. Given the prognostic power and clinical use of tum...
| Publicado en: | ISRN Oncology pp. 1 - 13 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104061012&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104061012 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20905661 BLI2 jtl: ISRN Oncology issn: 20905661 maglogo: N pubinfo: dt: 2013 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104061012 95274838 10.1155/2013/924971 104061012 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Gene Expression Profile Analysis of T1 and T2 Breast Cancer Reveals Different Activation Pathways. aug: au: Riis, Margit L. H. Xi Zhao Kaveh, Fateme Vollan, Hilde S. Nesbakken, Anne-Jorunn Solvang, Hiroko K. Lüders, Torben Bukholm, Ida R. K. Kristensen, Vessela N. affil: Department of Surgery, Akershus University Hospital, 1478 Lørenskog, Norway; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway sug: subj: Breast Neoplasms Familial and Genetic Gene Expression Neoplasm Staging Human Female Academic Medical Centers Norway Early Intervention Microarray Analysis Utilization Kaplan-Meier Estimator Utilization Prospective Studies Multivariate Analysis Funding Source Female ab: Breast cancers today are of predominantly T1 (0.1 ≥ 2.0 cm) or T2 (> 2 ≤ 5cm) categories due to early diagnosis. Molecular profiling using microarrays has led to the notion of breast cancer as a heterogeneous disease both clinically and molecularly. Given the prognostic power and clinical use of tumor size, the purpose of this study was to search for molecular signatures characterizing clinical T1 and T2. In total 46 samples were included in the discovery dataset. After adjusting for hormone receptor status, lymph node status, grade, and tumor subclass 441 genes were differently expressed between T1 and T2 tumors. Focal adhesion and extracellular matrix receptor interaction were upregulated in the smaller tumors while p38MAPK signaling and immune-related pathways were more dominant in the larger tumors.The T-size signature was then tested on a validation set of 947 breast tumor samples. Using the T-size expression signatures instead of tumor size leads to a significant difference in risk for distant metastases (P < 0.001). If further confirmed, this molecular signature can be used to select patients with tumor category T1 who may need more aggressive treatment and patients with tumor category T2 who may have less benefit from it. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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