DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects.
With the introduction of diffusion tensor imaging (DTI), structural differences in white matter (WM) architecture between psychiatric populations and healthy controls can be systematically observed and measured. In particular, DTI-tractography can be used to assess WM characteristics over the entire...
| Publicado en: | Brain Imaging & Behavior Vol. 7; no. 2; pp. 129 - 140 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104071954&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104071954 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2013 vid: 7 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104071954 NLM23070746 2012102319 10.1007/s11682-012-9202-3 NLM23070746 PMC3572298 104071954 ppf: 129 ppct: 11 formats: fmt: @attributes: type: P tig: atl: DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects. aug: au: Torgerson, Carinna M Irimia, Andrei Leow, Alex D Bartzokis, George Moody, Teena D Jennings, Robin G Alger, Jeffry R Van Horn, John Darrell Altshuler, Lori L affil: Laboratory of Neuro Imaging (LONI), Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles E. Young Dr. S, Los Angeles, CA, 90095, USA, carinnat@gmail.com. sug: subj: Bipolar Disorder Telencephalon Pathology Magnetic Resonance Imaging Nerve Fibers Pathology Adult Bipolar Disorder Drug Therapy Female Male Middle Age Affective Disorders Drug Therapy Affective Disorders Psychotropic Drugs Therapeutic Use Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: With the introduction of diffusion tensor imaging (DTI), structural differences in white matter (WM) architecture between psychiatric populations and healthy controls can be systematically observed and measured. In particular, DTI-tractography can be used to assess WM characteristics over the entire extent of WM tracts and aggregated fiber bundles. Using 64-direction DTI scanning in 27 participants with bipolar disorder (BD) and 26 age-and-gender-matched healthy control subjects, we compared relative length, density, and fractional anisotrophy (FA) of WM tracts involved in emotion regulation or theorized to be important neural components in BD neuropathology. We interactively isolated 22 known white matter tracts using region-of-interest placement (TrackVis software program) and then computed relative tract length, density, and integrity. BD subjects demonstrated significantly shorter WM tracts in the genu, body and splenium of the corpus callosum compared to healthy controls. Additionally, bipolar subjects exhibited reduced fiber density in the genu and body of the corpus callosum, and in the inferior longitudinal fasciculus bilaterally. In the left uncinate fasciculus, however, BD subjects exhibited significantly greater fiber density than healthy controls. There were no significant differences between groups in WM tract FA for those tracts that began and ended in the brain. The significance of differences in tract length and fiber density in BD is discussed. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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