Dynamic changes of FDG uptake and clearance in normal tissues.
Purpose: This study aims to evaluate dynamic 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) uptake in normal tissues.Procedures: Thirty male patients underwent FDG positron emission tomography (PET)/computed tomography imaging at 1, 2, and 3 h after tracer injection. Standardized uptake values (SUV) were o...
| Publicado en: | Molecular Imaging & Biology Vol. 15; no. 3; pp. 345 - 353 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104072625&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104072625 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2013 vid: 15 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104072625 NLM23090853 2012112267 10.1007/s11307-012-0600-0 NLM23090853 104072625 ppf: 345 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Dynamic changes of FDG uptake and clearance in normal tissues. aug: au: Cheng, Gang Alavi, Abass Lim, Esther Werner, Thomas J Del Bello, Catherine V Akers, Scott R affil: Department of Radiology, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA, 19104, USA, gangcheng99@yahoo.com. sug: subj: Fludeoxyglucose F 18 Pharmacokinetics Immunity Aged Aged, 80 and Over Female Heart Radiography Human Male Middle Age Time Factors Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: This study aims to evaluate dynamic 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) uptake in normal tissues.Procedures: Thirty male patients underwent FDG positron emission tomography (PET)/computed tomography imaging at 1, 2, and 3 h after tracer injection. Standardized uptake values (SUV) were obtained in regions of interest of normal tissues.Results: The aorta (blood pool), liver, and spleen FDG activity demonstrated significantly and continuously decreased activity from 1 to 2 and 2 to 3 h, while FDG uptake in the lungs, pancreas, lymph nodes, and skeletal muscle decreased from 1 to 2 h only. In contrast, the left ventricular myocardium demonstrated two patterns of dynamic changes: myocardium with higher FDG uptake (SUVmax ≥ 3.25) on the initial images had more remarkable increased activity on the delayed images, while myocardium with lower FDG uptake (SUVmax < 3.25) on the initial imaging had no increased uptake on delayed imaging. Increased FDG uptake was also observed in the bones on the delayed images. No significant changes of FDG uptake were noted in the parotid gland, thyroid gland, and prostate gland.Conclusions: These findings may help nuclear medicine physicians when comparing images performed at different time points, when using FDG uptake in internal reference regions as a relative indicator of FDG uptake in a specific lesion, and when reading a delayed FDG PET imaging. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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