Novel parameters indicate significant differences in severity of obstructive sleep apnea with patients having similar apnea-hypopnea index.
Sleep apnea-hypopnea syndrome (SAHS) causes impairment of daytime functions and increases risk of cardiovascular diseases. Apnea-hypopnea index (AHI), currently used for the estimation of the severity of SAHS, does not contain information on the morphology or duration aspects of the breathing cessat...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 51; no. 6; pp. 697 - 709 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2013
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104072799&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104072799 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jun2013 vid: 51 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104072799 NLM23417543 2012112721 10.1007/s11517-013-1039-4 NLM23417543 104072799 ppf: 697 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Novel parameters indicate significant differences in severity of obstructive sleep apnea with patients having similar apnea-hypopnea index. aug: au: Kulkas, Antti Tiihonen, Pekka Julkunen, Petro Mervaala, Esa Töyräs, Juha affil: Department of Clinical Neurophysiology, Seinäjoki Central Hospital, Hanneksenrinne 6, 60220, Seinäjoki, Finland, antti.kulkas@epshp.fi. sug: subj: Severity of Illness Indices Sleep Apnea, Obstructive Diagnosis Adult Aged Clinical Assessment Tools Human Male Middle Age Oxygen Blood Prospective Studies Retrospective Design Sleep Apnea, Obstructive Blood Time Factors Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male ab: Sleep apnea-hypopnea syndrome (SAHS) causes impairment of daytime functions and increases risk of cardiovascular diseases. Apnea-hypopnea index (AHI), currently used for the estimation of the severity of SAHS, does not contain information on the morphology or duration aspects of the breathing cessations and related oxygen desaturations. Longer breathing cessations and deeper desaturations may have more severe consequences than shorter and shallower ones. To address these issues, novel parameters containing information on the duration and morphology of breathing cessations and oxygen desaturations were calculated and evaluated on 160 male patients (40 patients in normal, mild, moderate and severe AHI severity categories). Obstruction and desaturation duration parameters consist of sum of event durations normalized with the total analysed time. Desaturation severity is a sum of desaturation event areas normalized with total analysed time and obstruction severity parameter is a sum of the products of apnea and hypopnea durations and related desaturation areas normalized with total analysed time. The median follow-up time of the patients was 183 months (range 154-215 months). The 40 patients in each category were further divided into subgroups A and B with lowest and highest novel parameter values, respectively. AHI showed no differences between the subgroups. Mortality was increased in subgroups B compared to subgroups A. The correlation of the novel parameters with AHI was only moderate and the parameter values were partially overlapping between the AHI severity categories. This suggests that patients with similar AHI may in fact suffer from SAHS of very different severity. Thus, the present results suggest that the novel parameters could bring new insight to the individual estimation of the severity of SAHS. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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